Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 20, Problem 27P

An allele of the G6PD gene acts in a recessive manner to cause sensitivity to fava beans, resulting in a hemolytic reaction (lysis of red blood cells) after ingestion of the beans. The same allele also confers dominant resistance to malaria. The heterozygote has an advantage in a region where malaria is prevalent. Will the equilibrium frequency (qe ) be the same for an African and a North American country? What factors affect qe?

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In a certain population in the US, the frequency of CCR5-Δ32 homozygous individuals is 1%. Assuming genetic equilibrium, what is the frequency of heterozygotes in this population?
An allele of the G6PD gene acts in a recessive manner to cause sensitivity to fava beans, resulting in ahemolytic reaction (lysis of red blood cells) afteringestion of the beans. The same allele also confersdominant resistance to malaria. The heterozygote hasan advantage in a region where malaria is prevalent.Will the equilibrium frequency (qe) be the same foran African and a North American country? Whatfactors affect qe?
Describe the effect of malaria on the frequency of the HbS allele in areas where malaria is common:In areas with malaria, which individual would survive better and leave more offspring- an individual with two HbA alleles or an individual with one HbA allele and one HbS allele? Given this, would you expect the HbS allele to be common or rare in populations living with malaria?

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Genetics: From Genes to Genomes, 5th edition

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