Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 20, Problem 7P

A large, random mating population is started with the following proportion of individuals for the indicated blood types:

0.5 MM

0.2 MN

0.3 NN

This blood type gene is autosomal, and the M and N alleles are codominant.

a. Is this population at Hardy-Weinberg equilibrium?
b. What will be the allele and genotype frequencies after one generation under the conditions assumed for Hardy-Weinberg equilibrium?
c. What will be the allele and genotype frequencies after two generations under the conditions assumed for Hardy-Weinberg equilibrium?
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An autosomal locus has alleles A and a.  The allele frequencies in a population at Hardy Weinberg equilibrium are p = Freq(A) = 0.5 q = Freq(a) = 0.5 What is the frequency of homozygous wild-type (AA) in this population? Enter a single number between 0 and 1, for example, 0.33
In a large, randomly mating human population, the frequencies of the IA, IB, and i alleles are 0.7, 0.2, and 0.1, respectively. Calculate the expected frequencies for each blood type. (show solution)
Three linked loci A, B, C (each with two alleles) in a random mating population have the gametic frequencies as shown below. Calculate the linkage disequilibrium D / Dmax between each pair of loci. Explain why the results seem paradoxical. Gamete АВС ABC AbC Abc aBC aBc abC abc Frequency 0.25 0.25 0.25 0.25

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Genetics: From Genes to Genomes, 5th edition

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