Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 20, Problem 17P

Androgenetic alopecia (pattern baldness) is a complex trait in humans governed by several genes, but suppose a human population exists in which a single autosomal allele determines pattern baldness. This allele is dominant in males and recessive in females. The population is in Hardy-Weinberg equilibrium, and 51% of the men are bald.

a. What is the allele frequency of the baldness allele among males?
b. What is the allele frequency of the baldness allele among females?
c. What percentage of the women in this population will exhibit pattern baldness?
d. Assuming random mating, what proportion of all matings should be between a bald man and a nonbald woman?
e. What percentage of the bald men in the population are heterozygotes?
f. If a nonbald couple produces a bald son, what is the probability that their next son will be bald?
g. A woman with androgenetic alopecia has a daughter, but nothing is known about the father. What is the probability that the daughter will be bald?
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Androgenetic alopecia (pattern baldness) is a complextrait in humans governed by several genes, but supposea human population exists in which a single autosomalallele determines pattern baldness. This allele is dominant in males and recessive in females. The population is in Hardy-Weinberg equilibrium, and 51% ofthe men are bald.a. What is the allele frequency of the baldness alleleamong males?b. What is the allele frequency of the baldness alleleamong females?c. What percentage of the women in this populationwill exhibit pattern baldness? d. Assuming random mating, what proportion of allmatings should be between a bald man and anonbald woman?e. What percentage of the bald men in the populationare heterozygotes?f. If a nonbald couple produces a bald son, what isthe probability that their next son will be bald?g. A woman with androgenetic alopecia has a daughter, but nothing is known about the father. What isthe probability that the daughter will be bald?
Albinos produce very little of the pigment melanin in their skin and hair. Albinism is inherited as a homozygous recessive trait. In North America, about 1 in 20,000 people are albinos. a. What is the frequency of the dominant allele for albinism?b. What is the frequency of albinos?c. What is the frequency of heterozygotes?
Cystic fibrosis (CF) is a recessive autosomal disorder. In certain populations of Northern European descent, the number of people born with this disorder is about 1 in 2500. Assuming Hardy- Weinberg equilibrium for this trait: A. What are the frequencies for the normal and CF alleles? B. What are the genotype frequencies of homozygous normal, heterozygous, and homozygous affected individuals? C. Assuming random mating, what is the probability that two phenotypically unaffected heterozygous carriers will choose each other as mates?

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Genetics: From Genes to Genomes, 5th edition

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