Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 20, Problem 28P
Explain why evolutionary biologists monitor selectively neutral polymorphisms as molecular clocks.
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Imagine a locus with two alleles. Mutation at this locus changes one allele to the other (i.e. it does not create a new allele). If the rate of mutation from allele 1 to allele 2 is 0.00005 and the rate of mutation from allele 2 to allele 1 is 0.01, what is the equilibrium frequency of allele 2 (Give your answer to 5 decimal places)?
Differentiate genetic drift from genetic shift.
What is genotype frequency?
How do you get the genotype frequency? Give formula and cite example.
Refer to the figure above. In their investigation of natural selection on Mc1r alleles (the gene that determines coat color) in Arizona pocket mice, Hoekstra et al. determined the frequency of the D and d alleles in each population. They also determined the frequency of alleles for two neutral mitochondrial DNA genes (genes that do not affect and are not linked to coat color). Why did the researchers include the mitochondrial DNA genes as part of their experimental design?
Allele change for the neutral mitochondrial genes serves as an experimental group and gives information on any general background genetic difference among these populations.
Allele change for the neutral mitochondrial genes serves as a control and determines coat-color differences among these populations.
Allele change for the neutral mitochondrial genes serves as an experimental group and gives information on coat-color differences among these populations.
Allele…
Chapter 20 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 20 - Choose the best matching phrase in the right...Ch. 20 - When an allele is dominant, why does it not always...Ch. 20 - A population with an allele frequency p of 0.5 and...Ch. 20 - Prob. 4PCh. 20 - Which of the following populations are at...Ch. 20 - A dominant mutation in Drosophila called Delta...Ch. 20 - A large, random mating population is started with...Ch. 20 - Prob. 8PCh. 20 - Prob. 9PCh. 20 - Two hypothetical lizard populations found on...
Ch. 20 - It is the year 1998, and the men and women sailors...Ch. 20 - Prob. 12PCh. 20 - In 1927, the ophthalmologist George Waaler tested...Ch. 20 - Prob. 14PCh. 20 - A gene has two alleles A frequency = p and a...Ch. 20 - Some people can taste the bitter compound...Ch. 20 - Androgenetic alopecia pattern baldness is a...Ch. 20 - Why is the elimination of a fully recessive...Ch. 20 - Tristan da Cunha is a group of small islands in...Ch. 20 - Small population size causes genetic drift because...Ch. 20 - Prob. 21PCh. 20 - A mouse mutation with incomplete dominance t =...Ch. 20 - In Drosophila, the vestigial wings recessive...Ch. 20 - Prob. 24PCh. 20 - You have identified an autosomal gene that...Ch. 20 - In Europe, the frequency of the CF allele causing...Ch. 20 - An allele of the G6PD gene acts in a recessive...Ch. 20 - Explain why evolutionary biologists monitor...Ch. 20 - What is the most straightforward evidence at the...Ch. 20 - In March 2013, the American Journal of Human...Ch. 20 - If you go back 40 generations into your biological...Ch. 20 - In Fig. 21.17, to what part of the world does...Ch. 20 - Predict the DNA sequences at the four nodes...Ch. 20 - A cladogram not drawn to scale for the taxonomic...Ch. 20 - As noted in Fig. 21.22, humans now living in...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- An hypothesis for the extinction of the dinosaurs is that the earth had been hit by a gigantic meteor that caused the death of those big reptiles. In that case the entire genetic pool of those animals has been destroyed, invalidating the Hardy-Weinberg equilibrium. In Genetics what is this type of gene frequency change called?arrow_forwardEvolution is driven by both nonrandom and random mechanisms. Identify the mechanisms of evolution that are random and comment on how they affect allele frequencies across generations.arrow_forwardHereditary genetics Population genetics Molecular genetics Answer Bank expressing exogenous transgenes to understand function calculating genotype frequencies to understand phenotype changes in a population researching how genetic drift impacted many species over the past thousand years observing phenotypes in offspring to understand gene inheritance studying DNA-protein interactions to understand gene regulation tracing pedigrees to determine patterns of gene transmission within a familyarrow_forward
- Genetic drift is often described as a “chance event.” Give other examples of chance events that could cause a genetic bottleneck.arrow_forwarda) Name and define the evolutionary processes that cause change in allele frequencies acrossgenerations. b) Describe how each process is expected to change allele frequencies across generations,including the following terms as appropriate:- genome-wide effects, loci-specific effects advantageous, deleterious, neutral- population size- speed of evolutionary changearrow_forwardGreen dragons are known by Knights of the Realm to be cleverer and thus more dangerous than both red and brown dragons. Molecular evolutionary alchemists working for the king have determined that a gene called FIZBAN has an average dN/dS (nonsynonymous rate/synonymous rate) ratio of 1.06 in green dragons, compared to 0.66 and 0.44 in red and brown dragons, respectively. What type of selection is this gene under in each dragon species? What type of trait might this gene contribute to? Give an evolutionary history of this gene in green dragons, including principles of population genetics in your answer.arrow_forward
- n class we investigated the reason cystic fibrosis is maintained in the human population in higher frequency than we expected given the deleterious effects of being homozygous at the CFTR gene. We calculated the actual mutation rate of the CFTR gene to be 6.7 x 10-7. The mutation rate expected under mutation-selection balance was 4 x 10-4. What is the most plausible explanation as to why cystic fibrosis is maintained in the human population at a higher frequency than we expect? a. Negative selection against the CFTR deleterious alleles is too weak to eliminate the alleles from the human population. b. Positive selection for the CFTR deleterious alleles is likely occurring in response to some other selective pressure in the human population, possibly resistance to typhoid fever. c. The CFTR gene has an exceedingly low mutation rate causing humans to have no genetic variation at that gene. d. The CFTR gene has an exceedingly high mutation rate and that is…arrow_forwardExplain how Darwinian evolution can decrease and increase the frequency of an allele or a more complex heritable traitarrow_forwardHow does the aminoacyl trna synthetases recognize which trna gets its amino acid? Define compare and contrast and give examples of natural selection and the impact on allele frequencies through mechanisms such as stabilizing selection directional selection and disruptive selection?In the human brain a great deal of synaptic pruning occurs in early childhood?arrow_forward
- Describe autotrophy and heterotrophy and provide a few examples of each that illustrate the diversity of how organisms obtain energy. What trade-offs are associated with the heterotrophic consumption of live animals versus dead plant materials? Why is the mutation critical to the formation of new alleles and central to the evolutionary process? Give examples and explain in terms of allele frequency changearrow_forwardExplain the role of genetic drift in shaping the genetic landscape of populations. Compare and contrast genetic drift with other evolutionary forces, such as natural selection, highlighting their respective contributions to population genetic variation.arrow_forwardWhat evolutionary factors can cause allele frequencies to change and possibly lead to a genetic polymorphism? Discuss the relative importance of each type of process.arrow_forward
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