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(a)
Interpretation:
The curved arrow mechanism for the given rearrangement reaction is to be shown.
Concept Introduction:
Benzylic protons are very acidic in nature as the conjugate base formed by the acid is resonance stabilized. Even a mild base can also abstract hydrogen ion. Intramolecular nucleophilic addition reaction takes place in those compounds in which nucleophile and electrophile both are present in the same compound.
(b)
Interpretation:
The curved arrow mechanism for the given rearrangement reaction is to be shown.
Concept Introduction:
Bromosuccinimide is a source of bromine radical. It can undergo various reactions. Nucleophilic addition reaction uses a nucleophile such as hydroxide ion which attacks at the electrophilic centre of the given compound to form nucleophilic addition product.
(c)
Interpretation:
The curved arrow mechanism for the given rearrangement reaction is to be shown.
Concept Introduction:
Acyl azide is heated in an inert solvent to form isocyanate with loss of nitrogen as by product. This reaction is known as Curtius rearrangement reaction. Isocyanate product of the rearrangement can be converted into amine by hydration in either an acid or base.
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Chapter 23 Solutions
EBK ORGANIC CHEMISTRY
- Compound F may be synthesised by the method attached Draw the isomer of compound B and explain which one would be the major product and why.arrow_forward(a) Draw two different halo ketones that can form A by an intramolecular alkylation reaction. (b) How can A be synthesized by an acetoacetic ester synthesis? of Aarrow_forwardGive the major organic product of the following reaction for a) or b)arrow_forward
- Provide the curved-arrow mechanism to account for the following electrophilic aromatic substitution reaction. .CI Cl2 FeCl3arrow_forwardSafrole, which is isolated from sassafras (Problem 21.33), can be converted to the illegal stimulant MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") by a variety of methods. (a) Devise a synthesis that begins with safrole and uses a nucleophilic substitution reaction to introduce the amine. (b) Devise a synthesis that begins with safrole and uses reductive amination to introduce the amine. NHCH9 MDMA safrolearrow_forwardSafrole, which is isolated from sassafras (Problem 21.33), can be converted to the illegal stimulant MDMA (3,4- methylenedioxymethamphetamine, “Ecstasy”) by a variety of methods. (a) Devise a synthesis that begins with safrole and uses a nucleophilic substitution reaction to introduce the amine. (b) Devise a synthesis that begins with safrole and uses reductive amination to introduce the amine.arrow_forward
- How would you account for the following :(a) Electrophilic susbstitution in case of aromatic amines takes place more readily than benzene.(b) Ethanamide is a weaker base than ethanamine.arrow_forward(a) Which is the correct structure of the alkyl halide substrate? (b) Which is the correct structure of the nucleophile?arrow_forward(b) Suggest a reasonable biosynthesis for the naturally occurring alkaloid coniine (isolated from hemlock), starting from octanoic acid. Coniinearrow_forward
- 22:43 10. Provide the following: the resonance structure of the intermediate that can resonate into the other intermediate that is given the product that results from the given resonance structure Specify which product is the kinetic product and which is the thermodynamic product . OH 50% H₂SO4 H~arrow_forwardGive a clear handwritten answer with explanation needed...give the mechanism of given bleow reactionarrow_forwardWhich compound(s) is (are) best suited for nucleophilic aromatic substitution reactions?arrow_forward
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