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EBK ORGANIC CHEMISTRY
6th Edition
ISBN: 8220103151757
Author: LOUDON
Publisher: MAC HIGHER
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Question
Chapter 26, Problem 26.20P
Interpretation Introduction
Interpretation:
The reaction of isoniazid with pyridoxal phosphate is to be stated.
Concept introduction:
One of the antibiotics used for treating the tuberculosis is known as isonoazid. It is mostly used with pyrazinamide or streptomycin to treat the active isoniazid. It action of work is to inhibit the growth of tuberculosis bacteria in the body.
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Students have asked these similar questions
1. Biogenic Amines are inactivated primarily by
a. Sulfonation
b. Glucoronidation
c. Aromatic hydroxylation
d. Methylation
2. A drug can exert its pharmacological effect only if it is
a. Protein bound
b. Protein unbound
c. Free drug
d. Both B & C
e. Both A & C
3. In order for the drug to be ready and available for absorption, it must be release first from its dosage form with the exception of:
a. Capsule
b. Tablet
c. Solution
d. Suspension
4. All of the following are true, except
a. Solubility increase with decrease particle size
b. Solubility increase with increase surface area
c. Solubility increase with increase particle size
d. Solubility decrease with decrease surface area
5. The rate in which the drug appears in the bloodstream is also known as
a. Half-life
b. Potency
c. Bioavailability
d. Area under the curve
Paroxetine (Paxil) is an antidepressant that is a member of a family of drugs known
as Selective Serotonin Reuptake Inhibitors (SSRIS). This family of drugs also includes
fluoxetine (Prozac) and sertraline (Zoloft). SSRIS work by inhibiting the reuptake of
the neurotransmitter serotonin in the synapses of the central nervous system follow-
ing release of serotonin during excitation of individual nerve cells. Between firings, the
serotonin is taken back up by a nerve cell in preparation for firing again. Inhibition of
reuptake has the effect of increasing the time serotonin molecules remain in the syn-
apses following excitation, leading to a therapeutic effect. In one synthesis of parox-
etine, the following reagents are used. Draw the structures of synthetic intermediates A
and B.
F
НО
SOCI,
A
B
HO
Pyridine
a. (S)-Penicillamine, an amino acid that does not occur in proteins, is used as a copper chelating agent to treat Wilson's disease, an inherited defect in copper metabolism. (R)-Penicillamine is toxic, sometimes causing blindness. Draw the structures of (R)- and (S)- penicillamine. b. What disulfide is formed from oxidation of (S)-penicillamine?
Chapter 26 Solutions
EBK ORGANIC CHEMISTRY
Ch. 26 - Prob. 26.1PCh. 26 - Prob. 26.2PCh. 26 - Prob. 26.3PCh. 26 - Prob. 26.4PCh. 26 - Prob. 26.5PCh. 26 - Prob. 26.6PCh. 26 - Prob. 26.7PCh. 26 - Prob. 26.8PCh. 26 - Prob. 26.9PCh. 26 - Prob. 26.10P
Ch. 26 - Prob. 26.11PCh. 26 - Prob. 26.12PCh. 26 - Prob. 26.13PCh. 26 - Prob. 26.14PCh. 26 - Prob. 26.15PCh. 26 - Prob. 26.16PCh. 26 - Prob. 26.17PCh. 26 - Prob. 26.18PCh. 26 - Prob. 26.19PCh. 26 - Prob. 26.20PCh. 26 - Prob. 26.21PCh. 26 - Prob. 26.22PCh. 26 - Prob. 26.23PCh. 26 - Prob. 26.24PCh. 26 - Prob. 26.25PCh. 26 - Prob. 26.26APCh. 26 - Prob. 26.27APCh. 26 - Prob. 26.28APCh. 26 - Prob. 26.29APCh. 26 - Prob. 26.30APCh. 26 - Prob. 26.31APCh. 26 - Prob. 26.32APCh. 26 - Prob. 26.33APCh. 26 - Prob. 26.34APCh. 26 - Prob. 26.35APCh. 26 - Prob. 26.36APCh. 26 - Prob. 26.37APCh. 26 - Prob. 26.38APCh. 26 - Prob. 26.39APCh. 26 - Prob. 26.40APCh. 26 - Prob. 26.41APCh. 26 - Prob. 26.42APCh. 26 - Prob. 26.43APCh. 26 - Prob. 26.44APCh. 26 - Prob. 26.45APCh. 26 - Prob. 26.46APCh. 26 - Prob. 26.47APCh. 26 - Prob. 26.48APCh. 26 - Prob. 26.49APCh. 26 - Prob. 26.50APCh. 26 - Prob. 26.51APCh. 26 - Prob. 26.52APCh. 26 - Prob. 26.53AP
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