Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 8, Problem 103P
A study is being planned to assess whether a topical antiallergic eye drop is effective in preventing the signs and symptoms of allergic conjunctivitis. In a pilot study, at an initial visit, participants are given an allergen challenge; that is, they are subjected to a substance that provokes allergy signs (e.g., cat dander) and their redness score is noted 10 minutes after the allergen challenge (visit 1 score). At a follow-up visit, the same procedure is followed, except that participants are given an active eye drop in one eye and the placebo in the fellow eye 3 hours before the challenge; a visit 2 score is obtained 10 minutes after the challenge. The data collected are shown in Table 8.26.
Table 8.26 Effect of an eye drop in reducing ocular redness among participants subjected to an allergen challenge
aThe redness score
Suppose we want to estimate the number of participants needed in the main study so that there is a 90% chance of finding a significant difference between active and placebo eyes using a two-sided test with a significance level of .05. We expect the active eyes to have a mean redness score 0.5 unit less than that of the placebo eyes. How many participants are needed in the main study?
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Chapter 8 Solutions
Fundamentals of Biostatistics
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