Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Videos
Textbook Question
thumb_up100%
Chapter 8, Problem 20P
The drug diflunisal is used to treat mild to moderate pain due to osteoarthritis (OA) and rheumatoid arthritis (RA). The ocular effects of diflunisal had not been considered until a study was conducted on its effect on intraocular pressure in glaucoma patients who were already receiving maximum therapy for glaucoma [5].
The change in intraocular pressure after administration of diflunisal among 30 patients whose standard therapy was topical drugs only was −0.7 ± 2.1 mm Hg. Assess the statistical significance of these results.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
A research on the effect of duodenal infusion of donor feces for recurrent Clostridium difficile examined patients with C. difficile infections which cause persistent diarrhea. Some patients were given the antibiotic vancomycin, while others were given a fecal transplant. At alpha = 0.01, test if the result is dependent on the type of treatment given.
In recent years, concerns have been expressed about adverse health effects from amalgam dental restorations, which include mercury. The table below shows results from a study in which some patients were treated with amalgam restorations and others were treated with composite restorations that do not contain mercury (based on data from “Neuropsychological and Renal Effects of Dental Amalgam in Children,” by Bellinger, et al., Journal of the American Medical Association, Vol. 295, No. 15). Use a 0.05 significance level to test for independence between the type of restoration and sensory disorders. Do amalgam restorations appear to affect sensory disorders?
Amalgam
Composite
Sensory disorder
36
28
No sensory disorder
231
239
In an observational study, it was noticed that people that eat more chocolate tend to have better blood flow than the general population. Researchers wonder whether the improved blood flow might be caused by flavanols (a molecule found in many foods). Dark chocolate contains a high concentration of flavanols, but milk chocolate contains a much lower concentration. How could the researchers design an experiment to determine the effects of flavanol on blood flow from the different types of chocolate?
Chapter 8 Solutions
Fundamentals of Biostatistics
Ch. 8 - Find the lower 2.5th percentile of an F...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...
Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - Refer to the data in Table 2.13. Table 2.13...Ch. 8 - Refer to the data in Table 2.13. What is the...Ch. 8 - Refer to the data in Table 2.13. Perform the...Ch. 8 - Refer to the data in Table 2.13. What is the...Ch. 8 - Refer to the data in Table 2.13. Compute a 95% CI...Ch. 8 - The drug diflunisal is used to treat mild to...Ch. 8 - The drug diflunisal is used to treat mild to...Ch. 8 - The drug diflunisal is used to treat mild to...Ch. 8 - The drug diflunisal is used to treat mild to...Ch. 8 - A study in Pittsburgh measured various...Ch. 8 - A study in Pittsburgh measured various...Ch. 8 - A 1980 study was conducted whose purpose was to...Ch. 8 - A 1980 study was conducted whose purpose was to...Ch. 8 - A 1980 study was conducted whose purpose was to...Ch. 8 - A camera has been developed to detect the presence...Ch. 8 - A camera has been developed to detect the presence...Ch. 8 - A camera has been developed to detect the presence...Ch. 8 - Prob. 31PCh. 8 - Prob. 32PCh. 8 - Prob. 33PCh. 8 - A possible important environmental determinant of...Ch. 8 - A possible important environmental determinant of...Ch. 8 - A possible important environmental determinant of...Ch. 8 - A possible important environmental determinant of...Ch. 8 - Prob. 38PCh. 8 - The degree of clinical agreement among physicians...Ch. 8 - The degree of clinical agreement among physicians...Ch. 8 - The degree of clinical agreement among physicians...Ch. 8 - The degree of clinical agreement among physicians...Ch. 8 - The degree of clinical agreement among physicians...Ch. 8 - Ten patients with advanced diabetic nephropathy...Ch. 8 - Ten patients with advanced diabetic nephropathy...Ch. 8 - Ten patients with advanced diabetic nephropathy...Ch. 8 - Ten patients with advanced diabetic nephropathy...Ch. 8 - A study was conducted of genetic and environmental...Ch. 8 - A study was conducted of genetic and environmental...Ch. 8 - Prob. 51PCh. 8 - Prob. 52PCh. 8 - Prob. 53PCh. 8 - Prob. 54PCh. 8 - Prob. 55PCh. 8 - Prob. 56PCh. 8 - Prob. 57PCh. 8 - Prob. 58PCh. 8 - Prob. 59PCh. 8 - Prob. 60PCh. 8 - Prob. 61PCh. 8 - Prob. 62PCh. 8 - Prob. 63PCh. 8 - A study was conducted [12] comparing muscle...Ch. 8 - Prob. 65PCh. 8 - A clinical trial compared percutaneous...Ch. 8 - Prob. 68PCh. 8 - Prob. 69PCh. 8 - An experiment was conducted to examine the...Ch. 8 - An experiment was conducted to examine the...Ch. 8 - An experiment was conducted to examine the...Ch. 8 - Prob. 73PCh. 8 - Prob. 74PCh. 8 - Prob. 75PCh. 8 - Prob. 77PCh. 8 - A study was performed looking at the effect of...Ch. 8 - A study was performed looking at the effect of...Ch. 8 - A study was performed looking at the effect of...Ch. 8 - Prob. 81PCh. 8 - Prob. 82PCh. 8 - Prob. 83PCh. 8 - Tennis elbow is a painful condition that afflicts...Ch. 8 - Prob. 85PCh. 8 - Prob. 86PCh. 8 - Prob. 87PCh. 8 - Prob. 88PCh. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - Prob. 94PCh. 8 - Prob. 95PCh. 8 - Prob. 96PCh. 8 - Prob. 98PCh. 8 - A study was performed to determine the effect of...Ch. 8 - A study was performed to determine the effect of...Ch. 8 - A study was performed to determine the effect of...Ch. 8 - A study was performed to determine the effect of...Ch. 8 - A study is being planned to assess whether a...Ch. 8 - A study is being planned to assess whether a...Ch. 8 - Prob. 105PCh. 8 - Prob. 106PCh. 8 - Left ventricular mass (LVM) is an important risk...Ch. 8 - Left ventricular mass (LVM) is an important risk...Ch. 8 - Prob. 109PCh. 8 - Prob. 110PCh. 8 - Prob. 111PCh. 8 - A study sought to demonstrate that soy beans...Ch. 8 - Prob. 113PCh. 8 - A study sought to demonstrate that soy beans...Ch. 8 - study was recently reported comparing the effects...Ch. 8 - study was recently reported comparing the effects...Ch. 8 - study was recently reported comparing the effects...Ch. 8 - study was recently reported comparing the effects...Ch. 8 - The Diabetes Prevention Study was a randomized...Ch. 8 - Prob. 122PCh. 8 - Prob. 123PCh. 8 - Prob. 124PCh. 8 - Prob. 125PCh. 8 - Prob. 126PCh. 8 - Prob. 127PCh. 8 - A study looked at the influence of retirement on...Ch. 8 - Cigarette smoking has important health...Ch. 8 - Cigarette smoking has important health...Ch. 8 - Cigarette smoking has important health...Ch. 8 - Cigarette smoking has important health...Ch. 8 - Cigarette smoking has important health...Ch. 8 - Prob. 134PCh. 8 - Prob. 135PCh. 8 - Prob. 136PCh. 8 - Prob. 137PCh. 8 - Prob. 138PCh. 8 - Prob. 142PCh. 8 - Prob. 143PCh. 8 - Prob. 144PCh. 8 - Prob. 145PCh. 8 - A study of genetic factors related to coronary...Ch. 8 - A study of genetic factors related to coronary...Ch. 8 - A study of genetic factors related to coronary...Ch. 8 - Prob. 149PCh. 8 - Prob. 150PCh. 8 - Prob. 151PCh. 8 - Prob. 152PCh. 8 - Prob. 153PCh. 8 - Prob. 154PCh. 8 - Prob. 155PCh. 8 - An individual has been exercising at a local gym...Ch. 8 - Prob. 157PCh. 8 - Suppose we have two groups with sample sizes of 8...Ch. 8 - Suppose we have two groups with sample sizes of 8...Ch. 8 - Suppose we have two groups with sample sizes of 8...Ch. 8 - In a 5-year follow-up of bilateral stimulation of...Ch. 8 - In a 5-year follow-up of bilateral stimulation of...Ch. 8 - In a 5-year follow-up of bilateral stimulation of...Ch. 8 - The following data are from a study on Botox...Ch. 8 - The following data are from a study on Botox...Ch. 8 - Prob. 166PCh. 8 - Prob. 167PCh. 8 - Prob. 168PCh. 8 - The EPIC-Norfolk study, a study of diet and cancer...Ch. 8 - Prob. 170PCh. 8 - Prob. 171PCh. 8 - Prob. 172PCh. 8 - Prob. 173PCh. 8 - Prob. 174PCh. 8 - Prob. 175PCh. 8 - Prob. 176P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, statistics and related others by exploring similar questions and additional content below.Similar questions
- J 2 RCT was conducted to evaluate efficacy and safety of drug simvastatin compared to placebo in reducing mortality and morbidity in patients with coronary heart disease. Subjects were followed up on average 5.4 years. Over the duration of the follow-up, 63 subjects died due to heart attack among 2,223 subjects in the placebo group compared to 30 deaths among 2,221 patients in the simvastatin drug group. 1. What is the Relative Risk or death from the heart attack in the simvastatin group?arrow_forwardOne of the purposes of an investigation by Porcellini et al. was to investigate the effect on CD4 T cell count of administration of intermittent interleukin (IL-2) in addition to highly active antiretroviral therapy (HAART). The following table shows the CD4 T cell count at baseline and then again after 12 months of HAART therapy with IL-2. Do the data show, at the 0.05 level, a significant change in CD4 T cell count?arrow_forwardCompare the two separate scatterplots. In particular, how do the associtation compare between women with pets vs. women without pets? Does one group have more variation in systolic blood pressure than the other? If so, for which group? Does systolic blood pressure seem higher for common ages between the two groups? If so, for which group?arrow_forward
- why is the DV female drosophila Do you use a z or test for this problem?arrow_forwardA fast-food chain decided to carry out an experiment to assess the influence of advertising expenditure on sales. Different relative changes in advertising expenditure, compared to the previous year, were made in eight regions of the country, and resulting changes in sales levels were observed the accompanying table shows the results. Increase in advertising expenditure (%) 0 5 15 20 25 30 35 40 Increase in sales (%) 5 10 18 25 35 50 60 65 Determine the value of ∑X, ∑X2, ∑Y, ∑Y2, ∑XY. Where X represent independent variable and Y for dependent variable. Determine and interpret the coefficient of correlation between the two variables. Determine the value of regressions coefficients and write down the simple linear regression model.…arrow_forwardA fast-food chain decided to carry out an experiment to assess the influence of advertising expenditure on sales. Different relative changes in advertising expenditure, compared to the previous year, were made in eight regions of the country, and resulting changes in sales levels were observed the accompanying table shows the results. Increase in advertising expenditure (%) 0 5 15 20 25 30 35 40 Increase in sales (%) 5 10 18 25 35 50 60 65 Determine the value of ∑X, ∑X2, ∑Y, ∑Y2, ∑XY. Where X represent independent variable and Y for dependent variable. Determine and interpret the coefficient of correlation between the two variables. Determine the value of regressions coefficients and write down the simple linear regression model. Test the validity of the model…arrow_forward
- A survey of high school students was done to examine whether students had ever driven a car after consuming a substantial amount of alcohol (1=yes, 0=no). Data was collected on their sex (male/female), race (White/non-White), and grade level (9,10,11,12). Researchers realized that the impact of race on consuming alcohol before driving might vary by grade level and decided to fit the following model. Compute the OR of drinking before driving for students who self-reported as Black versus non-Black in the 9th grade, adjusting for gender. Hello, thank you for helping me out with this. I'm just confused about the concept of adjusting for gender in this case. I am not sure if I should plug in 0 and 1 for the gender and report those out separately or if I should take both odds ratios and divide them?arrow_forwardIn a study conducted in the Science Department of Faculty of Science, Technology and Human Development in a University; the researcher examined the influence of the drug succinylcholine on the circulation levels of androgens in the blood. Blood samples from wild, free-ranging deer were obtained via the jugular vein immediately after an intramuscular injection of succinylcholine using darts and a capture gun. Deer were bled again approximately 30 minutes after the injection and then released. The level of androgens at time of capture and 30 minutes later, measured in nanograms per milliliter (ng/ml), for 15 deers as in Table Q1. Assuming that the populations of androgen at time of injection and 30 minutes later are normally distributed:i) Find the average and standard deviation of this studyii)Determine the critical region of this problem.iii) Test at the 0.05 level of significance whether the androgen concentrations are altered after 30 minutes of restraint.arrow_forwardThe dose-response effect is best described as A. when similar studies produce similar results B. when all other possible causes are ruled out. C. when the value of the response variable changes in a meaningful way with the dosage of the suspected cause.arrow_forward
- What is the Zstat and the Critical Value of the above question?arrow_forwardSuppose a researcher is interested inthe effectiveness in a new childhood exercise program implemented in a SRS of schools across a particular county. In order to test the hypothesis that the new program decreases BMI (Kg/m2), the researcher takes a SRS of children from schools where the program is employed and a SRS from schools that do not employ the program and compares the results. Assume the following table represents the SRSs of students and their BMIs. Student intervention group BMI (kg/m2) Student control group BMI (kg/m2) A 18.6 A 21.6 B 18.2 B 18.9 C 19.5 C 19.4 D 18.9 D 22.6 E 24.1 F 23.6 A) Assuming that all the necessary conditions are met (normality, independence, etc.) carry out the appropriate statistical test to determine if the new exercise program is effective. Use an alpha level of 0.05. Do not assume equal variances.B) Construct a 95% confidence interval about your estimate for the average difference in BMI between the groups.arrow_forwardIt is hypothesized that there are fluctuations in norepinephrine (NE) levels which accompany fluctuations in affect with bipolar affective disorder (manic-depressive illness). Thus, during depressive states, NE levels drop; during manic states, NE levels increase. To test this relationship, researchers measured the level of NE by measuring the metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG in micro gram per 24 hour) in the patient's urine experiencing varying levels of mania/depression. Increased levels of MHPG are correlated with increased metabolism (thus higher levels) of central nervous system NE. Levels of mania/depression were also recorded on a scale with a low score indicating increased mania and a high score increased depression. The data is provided below. MHPG Affect 980 22 1209 26 1403 8 1950 10 1814 5 1280 19 1073 26 1066 12 880 23 776 28 a. Can MHPG significantly predict…arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Glencoe Algebra 1, Student Edition, 9780079039897...AlgebraISBN:9780079039897Author:CarterPublisher:McGraw Hill
Glencoe Algebra 1, Student Edition, 9780079039897...
Algebra
ISBN:9780079039897
Author:Carter
Publisher:McGraw Hill
Chi Square test; Author: Vectors Academy;https://www.youtube.com/watch?v=f53nXHoMXx4;License: Standard YouTube License, CC-BY