Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 8.3, Problem 2TYK
After a G-protein-coupled receptor is activated, what happens to the G protein for it to be active?
- The receptor binds to the G protein.
- The G protein exchanges GDP for GTP.
- The G protein dissociates into a and
- All of the above happen.
- None of the above happens.
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Students have asked these similar questions
An extracellular signaling molecule binds to cell surface receptor. This cell surface receptor changes shape and activates a trimeric G-protein. What kind of receptor is this?
a) Ion-channel coupled receptor
b) Receptor Tyrosine Kinase
c) G-Protein coupled receptor
d) All of the other answers are correct
e) Enzyme-coupled receptor
Which of the following is not correct about a second messenger system?
A. The activating hormone interacts with a receptor site on the plasma membrane.
B. The activating hormone activates an enzyme, most often adenylate cyclase
C. Activated adenylate cyclase catalyzes the transformation of AMP to cyclic AMP
D. Cyclic AMP causes the activation of protein kinase
E. None of these are correct.
When a signal molecule (hormone) binds at a G protein-coupled receptor, the G protein
a.
Binds with GTP
b.
Becomes deactivated
c.
Binds with cAMP
d.
Binds with a kinase
e.
Binds to the signal molecule
Chapter 8 Solutions
Principles of Biology
Ch. 8.1 - What is the signaling molecule in this example?Ch. 8.1 - Prob. 2CCCh. 8.1 - Prob. 3CCCh. 8.1 - A general reason for cell signaling is to respond...Ch. 8.1 - Prob. 2TYKCh. 8.1 - Prob. 3TYKCh. 8.2 - Prob. 1BCCh. 8.2 - Prob. 1TYKCh. 8.2 - Prob. 2TYKCh. 8.3 - Prob. 1CC
Ch. 8.3 - What has to happen for the a and subunits of the...Ch. 8.3 - Prob. 1TYKCh. 8.3 - After a G-protein-coupled receptor is activated,...Ch. 8.4 - Prob. 1TYKCh. 8.5 - Look ahead to Figures 13.9 and, in particular,...Ch. 8.5 - Prob. 1TYKCh. 8.5 - Prob. 2TYKCh. 8.6 - Prob. 1CCCh. 8.6 - Prob. 2CCCh. 8.6 - Prob. 3CCCh. 8.6 - Prob. 1TYKCh. 8.6 - Prob. 2TYKCh. 8 - Prob. 1TYCh. 8 - Prob. 2TYCh. 8 - Prob. 3TYCh. 8 - Prob. 4TYCh. 8 - Which of the following is not an example of a cell...Ch. 8 - Prob. 6TYCh. 8 - The EGF receptor functions as a receptor tyrosine...Ch. 8 - Prob. 8TYCh. 8 - Prob. 9TYCh. 8 - The benefit of second messengers in signal...Ch. 8 - Prob. 1CCQCh. 8 - Prob. 2CCQCh. 8 - Prob. 3CCQCh. 8 - Discuss and compare several different types of...Ch. 8 - Prob. 2CBQ
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- Which of the following statements most accurately describes what happens when an antagonist binds to a receptor? The antagonist binds non-covalently to the receptor and promotes internalisation of the receptor. Antagonist binding alters the structure of the receptor making it unable to function normally. At sufficiently high concentrations the antagonist can prevent the receptor from binding to its natural (endogenous) ligand. The antagonist-receptor complex binds to a heterotrimeric G protein forming a stable and inactive ternary complex.arrow_forwardFor a signal to be sent down an axon of a nerve cell, an action potential must be generated. This is done by.. Select one: a. G-protein coupled receptors bind ligand, a phosphorylation cascade occurs, this causes a change in charge of the membrane due to the addition of phosphates allowing Na+ channels to open. b. Ligand-gated K+ channels open, allowing K+ to rush out of the cell and depolarize that part of the membrane. This change in charge opens neighboring voltage-gated channels. c. Ligand-gated Na+ channels open, allowing Na+ to rush in. This then depolarizes that region of the membrane resulting in opening neighboring voltage-gated channels. d. Receptor tyrosine kinases have two Na+ molecules bind, this opens voltage-gated channels allowing the “signal” to pass down the axon.arrow_forwardSomeone goes for a jog first thing in the morning and encounters a squadron of javelinas, causing a release of epinephrine. Some of this circulating epinephrine binds to a G-alpha-s coupled receptor (GPCR) on the surface of muscle cells. Which of the following would occur in the muscle cell as a result of this activation? Nitric oxide synthesis would increase. cyclic AMP (cAMP) activity would increase. Phospholipase C (PLC) would hydrolyze (cut) the molecule PIP2. The levels of adenylate cyclase activity would decrease. The levels of adenylate cyclase activity would decrease. Which ligand is CORRECTLY matched with its characteristic? Group of answer choices Glucagon: stimulates the activation of the mitogen activated protein (MAP) kinase pathway Nitric oxide (NO): must bind to its target protien withn a few seconds because NO degrades rapidly Steroid hormone: produces a response in its target cells within seconds Acetylcholine: hydrophobic molecule that binds to…arrow_forward
- When activated extracellularly, G protein-coupled receptors (GPCRs) initiate which of the following? (select all that apply) a G protein signaling mechanism inside the cell. b) A G protein signaling mechanism outside the cell. c) Transporters to uptake degraded neurotransmitters for recycling. d) The release of neurotransmitter molecules into the postsynaptic cell.arrow_forwardWhich of the following types of amino acids may never be found in the transmembrane sections of G-protein coupled receptors? Alanine Arginine Valine None of the abovearrow_forwardPut the steps of the process of G-protein signal transduction in the order (1-4) in which they occur. Second messenger molecules are activated and amplify the signal A signal molecule binds to a receptor on the outside of the cell The alpha (a) subunit of the G-protein inside the cell moves and binds to a nearby enzyme The receptor changes shape, transducing the signal into the cellarrow_forward
- Which receptor undergoes clustering and autophosphorylation in response to activation by a signal? Group of answer choices: a)Ligand-gated ion channels b)Receptor Tyrosine Kinases (RTKs) c)G-Protein Coupled Receptors (GPCRs) d)Nuclear Receptorsarrow_forwardExcept for?, all of the following signals may trigger receptor conformational changes without reaching the plasma membrane. o a. Receptors for steroid hormones. Tyrosine kinase receptors are a kind of receptor that binds to tyrosine phosphatase. Voltage-gated ion channels (OC). G protein-coupled receptors (GPCRs).arrow_forwardWhich of the following best describes the type of receptor a beta-antagonist drugs acts on a.Ligand-regulated transmembrane enzymes b.Ion channel c.G protein-coupled receptor d.Intracellular lipid-soluble signalingarrow_forward
- In the cAMP second messenger pathways, Protein kinase A is directly activated by _________. A) Group of answer choices B) cAMP C) Phosphorylation D) a G protein E) a G protein coupled receptor F) an enzymearrow_forwardOne molecule of the hormone epinephrine, acting via a G-protein ‹ Adenyl cyclase ‹ cAMP-dependent protein kinase system, is able to cause the release of 108 molecules of glucose from the liver. This is an example of the second-messenger system acting as an ______________arrow_forwardWhich of the following is true of signal transduction mediated by protein tyrosine kinases production of cAMP phosphoinositides are activated arrestins compete with G-proteins phosphorylation of tyrosine residuesarrow_forward
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Intro to Cell Signaling; Author: Amoeba Sisters;https://www.youtube.com/watch?v=-dbRterutHY;License: Standard youtube license