Chapter 16, Problem 68TQ

Summary Introduction

To review:

The phenomenon of mutation in the IRS1(insulin receptor substrate 1) gene with obesity, which leads to a reduction in insulin sensitivity.

Introduction:

The insulin receptor comprises two large α-subunits and two β-subunits. α-Subunit binds to insulinthatleads to the activation of receptor tyrosine kinase activity. As a consequenc, ehe activation of receptor tyrosine kinase activity causes phosphorylation of several genes. Expression of more than 150 genes are altered by insulin binding, one of them is IRS (insulin receptor substrate 1).