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Organ Transplants Must Be Immunologically A burn victim receives a skin graft from her brother; however, her body rejects the graft a few weeks later. The procedure is attempted again, but this time the graft is rejected in a few days. Explain why the graft was rejected the first time and why it was rejected more rapidly the second time.

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 17, Problem 22QP
Textbook Problem
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Organ Transplants Must Be Immunologically

A burn victim receives a skin graft from her brother; however, her body rejects the graft a few weeks later. The procedure is attempted again, but this time the graft is rejected in a few days. Explain why the graft was rejected the first time and why it was rejected more rapidly the second time.

Summary Introduction

To explain: The reason for the rejection of skin graft in an individual when the graft is transplanted from the individual's brother. The reason for the faster rejection of graft when transplanted the second time.

Introduction: Each organism is different from another by the presence of specific MHC (major histocompatibility complex) on the cells. However, there is a 50% MHC similarity found between parents and children and 25% similarity found between siblings.

Explanation of Solution

In the given case, when a burn victim received the skin graft first time from her brother, the transplanted graft was not accepted by the victim’s body. This is due to activation of the immune system which recognizes the transplanted graft as a foreign substance. The B-cells and T-cells get activated and start generating an immune response against the graft. The graft was rejected in a few weeks. So, during the first time of transplantation primary immune response was generated...

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