Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 17, Problem 34RQ
Summary Introduction

To review:

The different types of noncovalent interactions that stabilize the structure of deoxyribose nucleic acid (DNA).

Introduction:

The DNA stores the genetic information of theorganisms. This genetic information is stored in the form of a genetic code. The genetic code is written in the form of nitrogenous bases such as adenine, thymine, cytosine, and guanine. These bases are arranged on two antiparallel strands and linked to each other by hydrogen bonds. The DNA is a stable structure and its stability is maintained by several noncovalent bonds.

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True or False for each question (       ) Guanine, Adenine, Uracil, and Cytosine are commonly found in both DNA and RNA.  (       ) The DNA nucleotide sequence was elucidated by Watson and Crick from considerations of x-ray structure data generated by Rosalind Franklin, Chargaff’s rule, and molecular modeling. (       ) The phosphodiester backbone in major grooves in DNA are closer together than in minor grooves.  (       )  Major grooves in DNA are often sites where DNA-binding proteins bind. (       ) Base stacking in DNA results in hydrophobic effects and van der Waals interactions that provide stability to the DNA double helix.  (       ) Due to stacking interaction, double-stranded DNA absorbs less light at 260 nm than light absorbed by single-stranded DNA.  (       ) DNA melting temperature (Tm) for a region of DNA is the temperature at which all of the DNA molecules are denatured to the single-stranded state.  (       ) Sequences rich in G-C base pairs have more stability than…

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Biochemistry: The Molecular Basis of Life

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