Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 17, Problem 8Q
Summary Introduction
To review:
The comparison between central dogma and reverse central dogma as given in the figure:
Introduction:
The central dogma of molecular biology is the flow of genetic information from deoxyribonucleic acid (DNA) to ribonucleic acid (RNA) and then to proteins. The central dogma was given by Francis Crick. All the living organisms follow this pattern of flow of information except retroviruses. Retroviruses perform reverse transcription.
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Chapter 17 Solutions
Biochemistry: The Molecular Basis of Life
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- For the mutations described below, categorize them in each of the following ways: [transition, transversion, insertion, or deletion]; [synonymous, missense, nonsense, frameshift, or regulatory]; [beneficial, deleterious, or neutral] a. A mutation in the SARS-CoV2 virus changes a codon in the gene encoding the spike protein from AAG to AAC. This mutation increases the ability of the virus to spread from person to person. b. Becker muscular dystrophy results in progressive wasting of skeletal and heart muscle tissue. A patient is found to have a mutation in the dystrophin gene (DMD) in the first nucleotide of intron 25. Normally, a G is in this position, but the patient has an A. c. Fur color in house cats is affected by several genes that encode pigment-producing enzymes. One such gene is found to have an additional C after position 45 in orange cats but not in black cats.arrow_forwardWhat enzyme is responsible for the production of viral DNA from a retrovirus?arrow_forwardWhat are retrovirus-like elements?arrow_forward
- For the mutations described below, categorize them in each of the following ways: [transition, transversion, insertion, or deletion]; [synonymous, missense, nonsense, frameshift, or regulatory]; [beneficial, deleterious, or neutral] A mutation in the SARS-CoV2 virus changes a codon in the gene encoding the spike protein from AAG to AAC. This mutation increases the ability of the virus to spread from person to person. Becker muscular dystrophy results in progressive wasting of skeletal and heart muscle tissue. A patient is found to have a mutation in the dystrophin gene (DMD) in the first nucleotide of intron 25. Normally, a G is in this position, but the patient has an A. Fur color in house cats is affected by several genes that encode pigment-producing enzymes. One such gene is found to have an additional C after position 45 in orange cats but not in black cats.arrow_forwardWhy are retroviruses prone to accumulating oncogenes?arrow_forwardWhich of the following is a known characteristic or procesds that can lead to genetic changes in some viruses? When two different viral strains of the same type of virus infect a single individual, reassortment/mixing of segmented genome pieces can occur, resulting in new combinations of segments. Genetic rearrangements of the viral genome occurs as a result of duplicate operons in the viral genome undergoing homologous recombination. Environmental conditions trigger the SOS response in viruses, and leads to generation of errors/mutations in the viral genome. Viral RNA polymerases display proofreading capability in replicating the viral genome of certain viruses.arrow_forward
- Rhinovirus and the flaviviruses have a _________ RNA genome, which ___________________ bind in order for translation to occur. As with most viruses with such genomes, they produce a ________________ (type of peptide), which is cleaved in order to produce the individual viral proteinsarrow_forwardWhat enzyme is used by a retrovirus to make a DNA copy of its genome?arrow_forwardAlthough many +ssRNA viruses use their genomr directly as mRNA retroviruses do not. instead their +RNA is transcribed into a DNA by a resverse transcriptase. what advantages do retroviruses gained by using reserve transcriptase?arrow_forward
- What is unique about Z-DNA that might make it a specific target during viral infection?arrow_forwardAfter a positive strand RNA virus ( Such as Coronaviruses) enters the host cell, the RNA is translated by ribosomes to create proteins associated with the virus (Such as, for example, the surface antigens like E and Spike proteins). How then, would the genetic material itself be replicated to be incorporated into the new viruses?.arrow_forwardMost humans are not easily infected by avian influenza. How, then, do DNA sequences from avian influenza become incorporated into human influenza?arrow_forward
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