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The Adaptive Immune Response Is a Specific Defense Against Infection The molecular weight of IgG is 150,000 kd. Assuming that the two heavy chains are equivalent, the two light chains are equivalent, and the molecular weight of the light chains is half that of the heavy chains, what are the molecular weights of each individual subunit?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 17, Problem 7QP
Textbook Problem
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The Adaptive Immune Response Is a Specific Defense Against Infection

The molecular weight of IgG is 150,000 kd. Assuming that the two heavy chains are equivalent, the two light chains are equivalent, and the molecular weight of the light chains is half that of the heavy chains, what are the molecular weights of each individual subunit?

Summary Introduction

To determine: Molecular weight of the individual subunits of the IgG

Introduction: The immunoglobulin is a Y-shaped structure, which consists of two identical light chain and two identical heavy chains. The chains are connected with each other by the help of the disulfide bond. Each immunoglobulin has a different structure and function.

Explanation of Solution

Immunoglobulin IgG has a molecular weight of 150,000 kd (kilo-Dalton). IgG consists of two identical light chains (LC) and two identical heavy chains (HC). The molecular weight of the light chain can be considered as half as that of the heavy chain. So, the molecular weight of individual subunit is calculated as follows:

2HC+2LC=150,000kd1HC=2LCLC=12HC150,000kd=2HC+2(12HC)150,000kd=

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