Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 17, Problem 1QSDC
Summary Introduction
To review:
The type of ncRNA (noncoding ribonucleic acid)that might have arisen during the RNA world and the one which arose after the modern RNA/DNA(deoxyribonucleic acid) /protein world.
Introduction:
Non-coding RNA isa functional RNA that is transcribed from DNA but cannot be translated to protein. There are two types of ncRNA; short and long ncRNA. The short ncRNA is further divided into microRNA (miRNA), piwi-interacting RNA (piRNA), short interfering (siRNA). They are involved in regulating and influencing human diseases.
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Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- The RNAi and the microRNA (miRNA) pathways share many components and characteristics. What unique feature distinguishes the microRNA pathway from RNAi? a) only the RNAi pathway is initiated by dsRNA molecules b) the miRNA pathway does not require Dicer c) the miRNA pathway does not require RISC. d) miRNAs have 100% complementarity with their mRNA targets to block translation e) siRNAs that act in RNAi have 100% complementarity with their mRNA targets resulting in endonucleolytic cleavagearrow_forwardAlthough exRNAs are found in many fluids within plants and animals, why are they usually found within vesicles or bound by proteins?arrow_forwardAn ncRNA may have the following functions: scaffold, guide, alterer of protein function or stability, ribozyme, blocker, and/or decoy. Which of these functions are mediated by each type of ncRNA listed next? Note: A singlencRNA may have more than one function. A. tRNAB. rRNAC. SRP RNAD. piRNAarrow_forward
- List and briefly describe four types of molecules that can bind to an ncRNA.arrow_forwardA double-stranded RNA has been generated by release/splicing out of an intron within the nucleus...outline the pathway taken to generate microRNA and its action on the shutdown of protein biosynthesisarrow_forwardAn ncRNA may have the following functions: scaffold, guide,alterer of protein function or stability, ribozyme, blocker, and/ordecoy. Which of those functions is/are mediated by each of thencRNAs listed next? (Note: A single ncRNA may have more thanone function.) A. HOTAIRB. RNA of RNasePC. microRNAD. crRNAarrow_forward
- Define the following terms: a. noncoding RNA b. miRNA c. siRNA d. snoRNA e. lncRNAarrow_forwardExplain the piRNAs (piwi-interacting RNAs) ? How are they used ?arrow_forwardMicroRNAs are noncoding RNAs that are ___________________ to the body of the organism. They search the __________________ in the cytoplasm for sequence complementary to that of the miRNA. When such a molecule is found, it is then targeted for __________________. RNAi is double-stranded RNA that is ____________________ to the organism. It is digested into ______________________ RNA which will then bind a complementary sequence on the mRNA of the organism, effectively protecting it from translating foreign sequences. exogenous methylation riboswitch destruction mitochondria endogenous Dicer mRNA rRNA DNA phosphorylation single-stranded RNA double-stranded RNA prokaryotic…arrow_forward
- Are the remaining 98% of human DNA are non-coding RNAs (ncRNAs: sncRNA and lncRNA) which are extensively transcribed and participate in the regulation of protein-coding genes by forming complex regulatory networks?arrow_forwardGiven that ncRNA can have separate protein interaction sequences and nucleotide interaction sequences, do you think a single ncRNA could guide different proteins to the same DNA sequence? Why or why not?arrow_forwardDefine the term RNAi.arrow_forward
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