Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 17, Problem 2CONQ
An ncRNA may have the following functions: scaffold, guide, alterer of protein function or stability, ribozyme, blocker, and/or decoy. Which of those functions is/are mediated by each of the ncRNAs listed next? (Note: A single ncRNA may have more than one function.)
A. HOTAIR
B. RNA of RNaseP
C. microRNA
D. crRNA
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An ncRNA may have the following functions: scaffold, guide,alterer of protein function or stability, ribozyme, blocker, and/ordecoy. Which of those functions is/are mediated by each of thencRNAs listed next? (Note: A single ncRNA may have more thanone function.)
A. HOTAIRB. RNA of RNasePC. microRNAD. crRNA
Imagine the four basic components of gene regulation are DNA, RNA, proteins, and small molecules. Which of these things can ncRNA interact with?
The RNAi and the microRNA (miRNA) pathways share many components and characteristics. What unique feature distinguishes the microRNA pathway from RNAi?
a) only the RNAi pathway is initiated by dsRNA molecules
b) the miRNA pathway does not require Dicer
c) the miRNA pathway does not require RISC.
d) miRNAs have 100% complementarity with their mRNA targets to block translation
e) siRNAs that act in RNAi have 100% complementarity with their mRNA targets resulting in endonucleolytic cleavage
Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- List five types of cancer in which ncRNAs can be involved.arrow_forwardGiven that ncRNA can have separate protein interaction sequences and nucleotide interaction sequences, do you think a single ncRNA could guide different proteins to the same DNA sequence? Why or why not?arrow_forwardAbnormalities in the expression of ncRNAs are associated witha. many forms of cancer.b. neurological disorders.c. cardiovascular diseases.d. all of the above.arrow_forward
- When an ncRNA functions as a decoy, ita. contains binding sites for many different proteins, therebypromoting the formation of a large complex.b. recognizes other ncRNAs and sequesters them, therebypreventing them from working.c. can alter its conformation, allowing it to switch betweenactive and inactivate conformations.d. may physically prevent or block a cellular process fromhappening.arrow_forwardList and briefly describe four types of molecules that can bind to an ncRNA.arrow_forwardWhat is the difference between an miRNA and an siRNA. How dothese ncRNAs affect mRNAs?arrow_forward
- Describe the ability of ncRNAs to bind to other molecules and macromolecules.arrow_forwardSome eukaryotic mRNAs contain an AU-rich element in the 3’ untranslated region. What would be the effect on gene regulation by a microRNA (miRNA) if the AU-rich element was mutated or deleted?arrow_forwardDefine the following terms: a. noncoding RNA b. miRNA c. siRNA d. snoRNA e. lncRNAarrow_forward
- a mutation in the gene encoding Dicer would most likely result in: A) a failure to break the H bonds holding the 2 strands of the siRNA together B) the inability to form H bonds betwen the siRNA and the complementary mRNA that it targets. C) the inability of the target mRNA to be cleaved upon H bonding with the siRNA D) a failure to produce siRNAs responsible for knocking down gene expression E) the failure to produce a dsRNA specific to your gene of interestarrow_forwardRNA interference is mediated by: a. miRNA b. tRNA c. sgRNA d. mRNAarrow_forwardPre-mRNAs in mitochondria are converted to maturemRNAs through which process?arrow_forward
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