Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 17, Problem 10CONQ
Look at Figure 17.6 and predict what would happen if the SRP RNA was unable to stimulate the GTPase activities of the GTP-binding proteins within SRP and the SRP receptor.
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Referring to Figure 18.5, predict what would happen if the SRPRNA was unable to stimulate the GTPase activities of the GTPbindingproteins within SRP and the SRP receptor.
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Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- Figure 9.10 In certain cancers, the GTPase activity of the RAS G-protein is inhibited. This means that the RAS protein can no longer hydrolyze GTP into GDP What effect would this have on downstream cellular events?arrow_forwardVery briefly, explain how a ligand binding to the extracellular receptor region of a GPCR causes a change in biological events inside the cell.arrow_forwardWhy is the GTPase activity of G proteins crucial to the proper functioning of a cell? Why have G proteins not evolved to catalyze GTP hydrolysis more efficiently?arrow_forward
- Which of the following domains would you not expect to see in the receptor for BMP4? A. A ligand-binding domain B. A transmembrane domain C. A cytoplasmic domain D. A DNA-binding domain E. All of the above would be seen in the receptor for BMP4arrow_forwardWhat is the function of Ras during tyrosine kinase cell signaling? a. It activates the opening of channel-linked receptors. b. It is an enzyme that synthesizes second messengers. c. It links the receptor protein to the MAP kinase pathway. d. It phosphorylates other enzymes as part of a pathway.arrow_forwardWhy is the GTPase activity of G proteins crucial to the proper functioning of a cell? Propose a theory as to why G proteins have not evolved to catalyze GTP hydrolysis more efficiently.arrow_forward
- Which of these BEST describes how the signal is transduced from the EGF receptor to the Ras protein? A. Ras is phosphorylated B. Ras is dephosphorylated C. Ras binds to a GTP molecule D. Ras hydrolyzes a GTP moleculearrow_forwardA mutation in Ras that prevents Ras from hydrolyzing GTP. Would cause? Why? A. Increased proliferation B. Decreased proliferationarrow_forwardWhich of the following would be expected to inhibit PKC activation by a GPCR ligand? phospholipase C inhibitor cAMP phosphodiesterase inhibitor Ras inhibitor MAP kinase inhibitorarrow_forward
- We saw that most cancer mutations in the ras/mapk pathway occur upstream of mapk rather than in mapk itself. what might be a reason for that?arrow_forwardThe NF-κB signaling pathway, an important pathway in immune response and inflammation, is shown in the image. One of the pathway steps is the phosphorylation of IκBα. Which of the following best describes the role IκBα phosphorylation plays in the signaling pathway and what the modification of IκBα does? IκBα activates the transcription factor. Phosphorylation of IκBα leads to phosphorylation and activation of the transcription factor. IκBα inhibits the activation of the transcription factor. Phosphorylation of IκBα signals for the nuclear transcription factor to transcribe DNA. IκBα inhibits the translocation of the transcription factor. Phosphorylation of IκBα signals for IκBα degradation and allows the transcription factor to enter the nucleus. IκBα activates the translocation of the transcription factor. Phosphorylation of IκBα leads to phosphorylation of the transcription factor, which allows the transcription factor to enter the nucleus.arrow_forwardWe have studied Ras signal transduction pathway. In an experiment, two different mutations were produced using different chemicals. The proteins with mutation are listed below. State what will be the effect of each mutation and explain whether it will result in cell proliferation or not. GEF protein GTPasearrow_forward
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