Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 17.6, Problem 1COMQ
Summary Introduction
Introduction:
Certain abnormalities in the expression of ncRNA (non- coding RNAs) produce diseases. ncRNA regulates the process of transcription through chromatin modifications, mRNA (messenger RNA) translation and functions of proteins. Due to overexpression and undue expression of certain ncRNA, diseases are likely to procure. Such abnormalities in the expression of ncRNA is a result of mutation of epigenetic effects that alter the gene expression of ncRNA encoding genes.
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Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- Explain how ncRNA uses complementary base pairing with DNA to affect gene expression.arrow_forwardWhen an ncRNA functions as a decoy, ita. contains binding sites for many different proteins, therebypromoting the formation of a large complex.b. recognizes other ncRNAs and sequesters them, therebypreventing them from working.c. can alter its conformation, allowing it to switch betweenactive and inactivate conformations.d. may physically prevent or block a cellular process fromhappening.arrow_forwardDiagram the fate of the dsRNA once it enters a cell, highlighting the enzymatic reactions that eventually result in down-regulation of gene function.arrow_forward
- In gene silencing, the “dicer” enzymea. assembles siRNAs into a RISC complex.b. unwinds the RISC complex.c. binds siRNA to mRNA sequences complementary to it.d. slices up double-stranded RNA moleculesarrow_forwardUnusually high levels of Mdr1 provide stem cells with a. Nutrients needed b. Protection of their genomes from mutagenic agents c. Apoptotic factors d. Ability to differentiatearrow_forwardExplain how ncRNAs may be targets in treating human diseases.arrow_forward
- Promoters are DNA sequences a. near a transcription start site b. bound to a repressor protein c. that inhibit transcription of a gene d. that stimulate ncRNA activityarrow_forwardAfter tmRNA releases an mRNA and aberrant polypeptide from a stuck ribosome, the resulting polypeptide will A) be translated B) be destroyed by a protease C) be inserted into the cell membrane D) be used to regulate gene expressionarrow_forwardChanges in a cell that affect micro RNAs lead to cancer because miRNAs... a. help a cell to maintain a tight control on protein levels in a cell. b. decrease the level of a specific protein. c. increase the level of a specific protein. d. prevent the Warburg effect.arrow_forward
- Illustrate the crRNA biogenesis ?arrow_forwardWhich of the following are possible reasons that a cell would regulate its expression of a gene? (Select all that apply.) (a) an increased need for a particular enzyme (b) a decreased need for a particular enzyme (c) increasing temperature in the external environment (d) changing needs as an organism ages (e) deatharrow_forwardWhat strategy does a genetically encoded calcium indicator look like to allow fluorescence imaging of only one cell type in an acute slice of the brain? A.The use of fluorescent protein expression inhibitors in other cells B.The injection of a recombinant virus causing the death of other cells C.The use of a promoter specific to these cells D.Activation of membrane receptors specific to these cellsarrow_forward
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