Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 17, Problem 13CONQ
Summary Introduction
To review:
The function of Cas1, Cas2, and Cas9 proteins for the defense in a bacterial genome.
Introduction:
The CRISPR-Cas system is a significant defense system in prokaryotes. It provides an effective defense against foreign invaders like bacteriophage, transposons, and plasmids. The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) locus contains a series of repeated sequences which are derived from the DNA of bacteriophage.
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Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- What changes can be made to an mRNA transcript to be used in a vaccine in order to change its stability?arrow_forwardWhy was the type II CRISPR-Cas9 system of S. pyogenes selected by several scientists as a model to learn how the CRISPR-Cas mechanism works?arrow_forwardWhat is it about the Cas9 protein that makes it an efficient DNAediting tool?arrow_forward
- Why is the CRISPR-Cas system of bacteria considered an adaptiveimmunity rather than an innate immunity?arrow_forwardUsing figure (a) above as guide, list the five components in the CRISPR-Cas9 bacterial defense system used against bacteriophage infection. In 25 words or less describe the role of each component of the system. (1) (2) (3) (4) (5)arrow_forwardHow was it experimentally proven that the spacer sequences in the CRISPR locus were the elements responsible for resistance to phage infection?arrow_forward
- What is meant by the term site-specific recombination as used in identifying the processes that lead to the integration of temperate bacteriophages into host bacterial chromosomes during lysogeny or to the formation of specialized transducing phage?arrow_forwardWhat role do CRISPR-Cas systems naturally play in bacteria?arrow_forwardWhat mechanism in the mRNA covid-19 vaccine allows the immune system to recognize the cell as altered or non-self?arrow_forward
- Briefly describe two approaches that are used to edit the germline in embryos using CRISPR-Cas9. Which approach leads to genetic mosaicism? What types of germline gene editing is approved and what type is banned?arrow_forwardThe bacteriophage genome consists of many genes encoding proteins that make up the head, collar, tail, and tail fibers. When these genes are transcribed following phage infection, how are these proteins synthesized, since the phage genome lacks genes essential to ribosome structure?arrow_forwardWhy is a host-cell tRNA needed for reverse transcription?arrow_forward
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