Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 17, Problem 5EQ
Summary Introduction
To review:
Compare miRNA (micro ribonucleic acid) oligonucleotides, locked
Introduction:
Cancer is a term that encompasses a collection of different related diseases. In cancer, an abnormal growth of cells occurs and spreads to different body tissues. Certain types of cancer can be treated by using certain modified chemical derivatives like, miRNA oligonucleotide, antagomirs, and locked nucleic acid.
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Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- miRNAs target endogenous mRNAs in a sequence-specific manner. Explain, conceptually, how one might identify potential mRNA targets for a given miRNA if you only know the sequence of the miRNA and the sequence of all mRNAs in a cell or tissue of interest.arrow_forwardWhat is a potential link between prostate cancer and miRNA-101?arrow_forwardDo you think it would be easier to mutate the GR receptor or treat someone with a miRNA to overcome the negative aspects of the stress response? Why?arrow_forward
- Compare and contrast the origins and functions of miRNA and siRNAarrow_forwardWhile miRNA response elements (MREs) may be located anywhere within an mRNA, they are most often found outside the coding region in the 5 or 3 UTR. Explain why this is likely the case given that miRNAs often target more than one mRNA.arrow_forwardCompare and contrast the roles of crRNA and tracrRNA in the defense against bacteriophagesprovided by the CRISPR-Cas systemarrow_forward
- Which of the following is NOT true of miRNAs? A. Pri-miRNAs are processed by Drosha in the nucleus to form pre-miRNAs which are cleaved by dicer in the cytoplasm to generate a miRNA. B. miRNAs always lead to the degradation of their mRNA targets. C. miRNAs can be encoded within the vertebrate genome within introns and within intergenic regions. D. miRNAs can generally target more than one mRNAarrow_forwardDefine about miRNA response elements (MREs) ?arrow_forwardCompare and contrast the roles of crRNA and tracrRNA in the defense process against bacteriophages provided by the CRISPRCas system.arrow_forward
- Molecules in higher eukaryotes that are directly involved in gene silencing include all of the following except a. miRNA b. argonaute c. microprocessor d. glycosylasearrow_forwardmiRNA molecules act as specificity factors, which direct effector proteins to target ______ molecules via base-pairing. A. RNA B. Carbohydrate C. Lipid D. DNA E. Proteinarrow_forwardList five types of cancer in which ncRNAs can be involved.arrow_forward
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