Whether “acyl CoA is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated. Concept introduction: The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH 2 , and NADH are produced in this reaction. The first stage of fatty acid oxidation is the activation of fatty acids in the outer mitochondrial membrane. The fatty acid is activated by CoA and ATP. The activated fatty acid-CoA is called acyl CoA. The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Question

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Answer 1

Question

Chapter 25, Problem 25.26EP

(a)

Interpretation Introduction

Interpretation:

Whether “acyl CoA is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The first stage of fatty acid oxidation is the activation of fatty acids in the outer mitochondrial membrane. The fatty acid is activated by CoA and ATP. The activated fatty acid-CoA is called acyl CoA.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(b)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine enters the inner mitochondrial membrane” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(c)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine is converted to carnitine” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(d)

Interpretation Introduction

Interpretation:

Whether “coenzyme A is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

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Given that malonate inhibits succinate dehydrogenase which of the following statements is TRUE? a. FADH2 results in only 4 H+ being pumped out of the mitochondrial matrix. b. All electron transport is inhibited. c. Transfer of electrons from NADH to Coenzyme Q (ubiquinone) is inhibited. d. Transfer of electrons from FADH2 to Coenzyme Q (ubiquinone) is inhibited. e. NADH results in only 4 H+ being pumped out of the mitochondrial matrix. Clear my choice

Which of the following statements are TRUE?Multiple answers are accepted for this question a .Two molecules of CO2 are produced each time a molecule of Acetyl-CoA is oxidized. b. During the first turn of the TCA Cycle the carbon atoms of Acetyl-CoA become CO2. c. The number of molecules of ATP that can be produced in the Citric Acid Cycle by substrate level phosphorylation of ADP from two molecules of Acetyl-CoA is 30. d. Fumarate contains a trans double bond. The cis isomer of Fumarate is Maleate which cannot serve as carbon source for a cell. e. Lack of O2 would decrease the rate of the Citric Acid Cycle in red blood cells. f. If a potent inhibitor of Succinyl-CoA Synthetaseis is applied to liver cells both energy production and synthesis of carbohydrate would be affected. g. The overall chemical changes that occur during one complete turn of the Citric Acid Cycle is the complete oxidation of one molecule of Acetyl-CoA plus the production of two molecules of CO2 plus the…

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Answer 2

Question

Chapter 25, Problem 25.26EP

(a)

Interpretation Introduction

Interpretation:

Whether “acyl CoA is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The first stage of fatty acid oxidation is the activation of fatty acids in the outer mitochondrial membrane. The fatty acid is activated by CoA and ATP. The activated fatty acid-CoA is called acyl CoA.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(b)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine enters the inner mitochondrial membrane” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(c)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine is converted to carnitine” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(d)

Interpretation Introduction

Interpretation:

Whether “coenzyme A is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

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Answer 3

Question

Chapter 25, Problem 25.26EP

(a)

Interpretation Introduction

Interpretation:

Whether “acyl CoA is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The first stage of fatty acid oxidation is the activation of fatty acids in the outer mitochondrial membrane. The fatty acid is activated by CoA and ATP. The activated fatty acid-CoA is called acyl CoA.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(b)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine enters the inner mitochondrial membrane” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(c)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine is converted to carnitine” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(d)

Interpretation Introduction

Interpretation:

Whether “coenzyme A is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

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Answer 4

Question

Chapter 25, Problem 25.26EP

(a)

Interpretation Introduction

Interpretation:

Whether “acyl CoA is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The first stage of fatty acid oxidation is the activation of fatty acids in the outer mitochondrial membrane. The fatty acid is activated by CoA and ATP. The activated fatty acid-CoA is called acyl CoA.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(b)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine enters the inner mitochondrial membrane” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(c)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine is converted to carnitine” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(d)

Interpretation Introduction

Interpretation:

Whether “coenzyme A is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

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Answer 5

Chapter 25, Problem 25.26EP

(a)

Interpretation Introduction

Interpretation:

Whether “acyl CoA is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The first stage of fatty acid oxidation is the activation of fatty acids in the outer mitochondrial membrane. The fatty acid is activated by CoA and ATP. The activated fatty acid-CoA is called acyl CoA.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(b)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine enters the inner mitochondrial membrane” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(c)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine is converted to carnitine” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

(d)

Interpretation Introduction

Interpretation:

Whether “coenzyme A is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Answer 6

Chapter 25, Problem 25.26EP

(a)

Interpretation Introduction

Interpretation:

Whether “acyl CoA is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The first stage of fatty acid oxidation is the activation of fatty acids in the outer mitochondrial membrane. The fatty acid is activated by CoA and ATP. The activated fatty acid-CoA is called acyl CoA.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Answer 7

Chapter 25, Problem 25.26EP

(a)

Interpretation Introduction

Interpretation:

Whether “acyl CoA is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The first stage of fatty acid oxidation is the activation of fatty acids in the outer mitochondrial membrane. The fatty acid is activated by CoA and ATP. The activated fatty acid-CoA is called acyl CoA.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Answer 8

(b)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine enters the inner mitochondrial membrane” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Answer 9

(b)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine enters the inner mitochondrial membrane” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Answer 10

(c)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine is converted to carnitine” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Answer 11

(c)

Interpretation Introduction

Interpretation:

Whether “acyl carnitine is converted to carnitine” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Answer 12

(d)

Interpretation Introduction

Interpretation:

Whether “coenzyme A is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

Answer 13

(d)

Interpretation Introduction

Interpretation:

Whether “coenzyme A is a product” in the mitochondrial matrix or in the mitochondrial intermembrane space in the carnitine shuttle system associated with the β-oxidation process has to be indicated.

Concept introduction:

The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed as the β-oxidation pathway. Acetyl CoA, FADH₂, and NADH are produced in this reaction.

The enzymes that are needed for the oxidation of fatty acid are located in the mitochondrial matrix. Acyl CoA cannot pass through the inner mitochondrial membrane to the mitochondrial matrix because it is too large. A shuttle mechanism that involves the molecule carnitine effects the entry of acyl CoA into the mitochondrial matrix.

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Solution Summary: The author explains that acyl CoA is a product in the mitochondrial matrix, and the carnitine shuttle system associated with the -oxidation process.

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