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Concept explainers
(a)
Interpretation:
Whether the statement “both processes occur in the mitochondrial matrix” contrasting the processes of lipogenesis and the β-oxidation pathway is true or false has to be identified.
Concept introduction:
The β-oxidation pathway is defined as a repetitive series of four biochemical reactions in which acyl CoA is degraded to acetyl CoA by the removal of two carbon atoms at a time. NADH and FADH2 are also produced in this pathway.
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
A cyclic process for the chain elongation occurs in the enzyme fatty acid synthase. The one turn of this cyclic process constitutes four reactions. The various intermediates formed in the process are associated with a carrier protein known as ACP.
(b)
Interpretation:
Whether the statement “both processes use ACP as a carrier molecule” contrasting the processes of lipogenesis and the β-oxidation pathway is true or false has to be identified.
Concept introduction:
The β-oxidation pathway is defined as a repetitive series of four biochemical reactions in which acyl CoA is degraded to acetyl CoA by the removal of two carbon atoms at a time. NADH and FADH2 are also produced in this pathway.
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
A cyclic process for the chain elongation occurs in the enzyme fatty acid synthase. The one turn of this cyclic process constitutes four reactions. The various intermediates formed in the process are associated with a carrier protein known as ACP.
(c)
Interpretation:
Whether the statement “both processes use the same reducing agents” contrasting the processes of lipogenesis and the β-oxidation pathway is true or false has to be identified.
Concept introduction:
The β-oxidation pathway is defined as a repetitive series of four biochemical reactions in which acyl CoA is degraded to acetyl CoA by the removal of two carbon atoms at a time. NADH and FADH2 are also produced in this pathway.
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
A cyclic process for the chain elongation occurs in the enzyme fatty acid synthase. The one turn of this cyclic process constitutes four reactions. The various intermediates formed in the process are associated with a carrier protein known as ACP.
(d)
Interpretation:
Whether the statement “both processes involve the same
Concept introduction:
The β-oxidation pathway is defined as a repetitive series of four biochemical reactions in which acyl CoA is degraded to acetyl CoA by the removal of two carbon atoms at a time. NADH and FADH2 are also produced in this pathway.
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
A cyclic process for the chain elongation occurs in the enzyme fatty acid synthase. The one turn of this cyclic process constitutes four reactions. The various intermediates formed in the process are associated with a carrier protein known as ACP.
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Chapter 25 Solutions
EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
- Five coenzymes are required by a-ketoglutarate dehydrogenase, the enzyme in the citric acid cycle that converts a-ketoglutarate to succinyl-CoA.a. Identify the coenzymes.b. Propose a mechanism for the reaction.arrow_forwardGiven that malonate inhibits succinate dehydrogenase which of the following statements is TRUE? a. FADH2 results in only 4 H+ being pumped out of the mitochondrial matrix. b. All electron transport is inhibited. c. Transfer of electrons from NADH to Coenzyme Q (ubiquinone) is inhibited. d. Transfer of electrons from FADH2 to Coenzyme Q (ubiquinone) is inhibited. e. NADH results in only 4 H+ being pumped out of the mitochondrial matrix. Clear my choicearrow_forwardWhich of the following statements about the ß-oxidation cycle is/are TRUE?A. The fatty acyl produced is shorter by 2 carbon atoms than the previous cycle.B. The two oxidation reactions involve both NADH and NADPH.C. Acetyl-CoA is produced in the hydration reaction.D. In the cleavage reaction, the bond between the α- and β- carbons become a double bund.arrow_forward
- Listed are some hypothetical medical conditions, describe their effect on cellular respiration (specifically refer to the effect they will have on energy production). a) A person is unable to take glucose into their cells. b) A mutation occurs in the ATP synthase protein and it is inactive. c) The mitochondrial inner membrane is very permeable to H+.arrow_forwardFor each of the following conditions, state whether this condition would be occurring during gluconeogenesis, glycolysis, or both in liver cells. a. Transporting malate from the cytosol into the mitochondria. _____________ b. Transporting pyruvate from the cytosol into the mitochondria. _____________ c. We would have an increased (or increasing) concentration of F26BP. __________ d. Increased concentration of F6P.__________ e. Hexokinase IV (or glucokinase) is found in the nucleus of the cell. __________ f. The enzyme that synthesizes/breaks down F26BP is phosphorylated. __________ g. Elevated levels of glucagon in the blood. ____________arrow_forwardCharacterize, in terms of number of carbon atomspresent, each of the following citric acid cycle changesas (1) a C4 to C4 change, (2) a C4 to C6 change, (3) a C5to C4 change, or (4) a C6 to C5 change.a. Oxaloacetate to citrateb. a-Ketoglutarate to succinyl CoAc. Fumarate to malated. Succinyl CoA to succinatearrow_forward
- Consider the following statements: (1) the products of the first two stages of cholesterol biosynthesis are, respectively, mevalonate (C6) and isopentyl pyrophosphate (2) Over 90 percent of the total dietary lipids are triaglycerols (3) The activation stages of fatty acid oxidation involves both CoA & ATP Choices: a. Only one of the statements is true b. All three statements are true c. Two of the three statements are true d. None of the statements are truearrow_forwardPyruvate is transformed to Acetyl-CoA in one of two ways: a. in the cytoplasm by an oxidative carboxylation process b.Through the mitochondrial matrix's oxidative decarboxylation mechanism C. In the mitochondrial matrix, via a dehydration process d.Through the liver's glucose-6-phosphatasearrow_forwardAll enzymes of the TCA cycle reside in the mitochondrial membrane. answer choices A.) True B.) Falsearrow_forward
- Define the following terms: a. thiolytic cleavage b. ketogenesis c. ketone bodies d. α-oxidation e. ACCarrow_forwardA patient who has been drinking large amounts of alcohol for long periods of time shows thefollowing symptoms: apathy, loss of memory, and a rhythmical to-and-fro motion of the eyeballs.Which of the following reactions are most likely to be affected in the patient? A. Conversation of pyruvate to acetyl-CoA B. Conversation of a-ketoglutarate to succinyl-CoA C. Both A and B D. Neither A nor Barrow_forwardProvide a simplified schematic presentation of mitochondrial β-oxidation. Include activation, mitochondrial transportation, important coenzymes and enzyme names. (Note that you can simply provide intermediate names or abbreviations here and not structures).arrow_forward
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