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Concept explainers
(a)
Interpretation:
Whether the occurrence of two different condensation reactions is a characteristic of (1) the β-oxidation pathway but not ketogenesis, (2) ketogenesis but not β-oxidation pathway, (3) both the β-oxidation pathway and ketogenesis or (4) neither the β-oxidation pathway nor ketogenesis has to be determined.
Concept introduction:
Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules.
β-oxidation is a catabolic process occurring in the body through which, fatty acid molecules are broken down in the mitochondria of the cells to generate energy. The process involves breaking down long fatty acid chains that have been converted to acyl CoA chains into smaller fatty acyl CoA chains. The fatty acid chain is broken down until the final acyl CoA chain that cannot be broken down any further. The end products of this
(b)
Interpretation:
Whether the occurrence of four distinct steps is a characteristic of (1) the β-oxidation pathway but not ketogenesis, (2) ketogenesis but not β-oxidation pathway, (3) both the β-oxidation pathway and ketogenesis or (4) neither the β-oxidation pathway nor ketogenesis has to be determined.
Concept introduction:
Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.
β-oxidation is a catabolic process occurring in the body through which, fatty acid molecules are broken down in the mitochondria of the cells to generate energy. The process involves breaking down long fatty acid chains that have been converted to acyl CoA chains into smaller fatty acyl CoA chains. The fatty acid chain is broken down until the final acyl CoA chain that cannot be broken down any further. The end products of this metabolic process are acetyl CoA, FADH2 and NADH. These three molecules later enter the Krebs cycle where they are used to produce ATP molecules.
(c)
Interpretation:
Whether the occurrence of thiolysis is a characteristic of (1) the β-oxidation pathway but not ketogenesis, (2) ketogenesis but not β-oxidation pathway, (3) both the β-oxidation pathway and ketogenesis or (4) neither the β-oxidation pathway nor ketogenesis has to be determined.
Concept introduction:
Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.
β-oxidation is a catabolic process occurring in the body through which, fatty acid molecules are broken down in the mitochondria of the cells to generate energy. The process involves breaking down long fatty acid chains that have been converted to acyl CoA chains into smaller fatty acyl CoA chains. The fatty acid chain is broken down until the final acyl CoA chain that cannot be broken down any further. The end products of this metabolic process are acetyl CoA, FADH2 and NADH. These three molecules later enter the Krebs cycle where they are used to produce ATP molecules.
(d)
Interpretation:
Whether the occurrence of a hydrogenation reaction is associated with (1) the β-oxidation pathway but not ketogenesis, (2) ketogenesis but not β-oxidation pathway, (3) both the β-oxidation pathway and ketogenesis or (4) neither the β-oxidation pathway nor ketogenesis has to be determined.
Concept introduction:
Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.
β-oxidation is a catabolic process occurring in the body through which, fatty acid molecules are broken down in the mitochondria of the cells to generate energy. The process involves breaking down long fatty acid chains that have been converted to acyl CoA chains into smaller fatty acyl CoA chains. The fatty acid chain is broken down until the final acyl CoA chain that cannot be broken down any further. The end products of this metabolic process are acetyl CoA, FADH2 and NADH. These three molecules later enter the Krebs cycle where they are used to produce ATP molecules.
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Chapter 25 Solutions
EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
- A. List all the materials required for beta-oxidation of fatty acids. How does this process differ from the Biosynthesis of fatty acids? B. Outline the pathway involved in the synthesis of cholesterol from six-carbon intermediate Mevalonate. C. Describe all the stages involved in the urea cycle (Transmination, Ammonia Transport, and stages of the urea cycle).arrow_forward(a) Briefly describe the relationship between intracellular malonyl-CoA levels in the liver and the control of ketogenesis. (b) Describe how the action of hexokinase IV helps the liver to buffer the level of blood glucose.arrow_forwardConsider the reactions of ketogenesis. (a) What role does acetyl-CoA play?(b) How many acetyl-CoA molecules are used in the production of the ketonebodies?(c) What is the essential role of ketone bodies during prolonged starvation?arrow_forward
- Which of the following statements about the ß-oxidation cycle is/are TRUE?A. The fatty acyl produced is shorter by 2 carbon atoms than the previous cycle.B. The two oxidation reactions involve both NADH and NADPH.C. Acetyl-CoA is produced in the hydration reaction.D. In the cleavage reaction, the bond between the α- and β- carbons become a double bund.arrow_forward1. What is the common metabolic pathway of these three nutrients? Explain the process involved. 2. Make a flow chart diagram of each step in Glycolysis. Identify the biochemical reactions in each step and its corresponding enzymes and coenzymes. 3. What metabolic products are formed from pyruvate in each case: a) anaerobic conditions in the body b) anaerobic conditions in yeast c) aerobic conditionsarrow_forwardIn the context of fatty acid oxidation to acetyl CoA, indicate whether each of the following substances is involved in (1) fatty acid activation, (2) fatty acid trans-port, or (3) b-oxidation pathway. More than one choice may be correct in a given situation. a. AMp b. FAD c. Acyl CoA d. H2Oarrow_forward
- A patient who has been drinking large amounts of alcohol for long periods of time shows thefollowing symptoms: apathy, loss of memory, and a rhythmical to-and-fro motion of the eyeballs.Which of the following reactions are most likely to be affected in the patient? A. Conversation of pyruvate to acetyl-CoA B. Conversation of a-ketoglutarate to succinyl-CoA C. Both A and B D. Neither A nor Barrow_forwardWhich of the following statement(s) is/are TRUE about ketogenesis? I. It is favored during a low carbohydrate, high fat diet II. Acetoacetate is not soluble in water. Group of answer choices: -Only II is correct. -Both I and II are correct. -Neither I nor II is correct. -Only I is correct.arrow_forwardWhich of the following statements is/are TRUE about fatty acid activation before β-oxidation? I. The process consumes energy equivalent to two moles of ATP. II. The fatty acid is activated by ATP to give a fatty acyl-CoA.arrow_forward
- Five coenzymes are required by a-ketoglutarate dehydrogenase, the enzyme in the citric acid cycle that converts a-ketoglutarate to succinyl-CoA.a. Identify the coenzymes.b. Propose a mechanism for the reaction. A-ketoglutarate dehydrogenase A-ketoglutarate succinyl-CoAOO OO O−O O− −O SCoA + CO2arrow_forwardCompare and contrast the following items related to lipid metabolism. Cite their main similarities/or differences. 1. Dehydrogenase enzyme vs. dehydratase enzyme(in context of lipid metabolism). 2. Steroid hormones vs. prostaglandins (in terms of their biosynthetic pathways). 3. Fatty acid synthase complex vs. pyruvate dehydrogenase complex.arrow_forwardIn the complete b-oxidation of stearic acid (18:0), a)how many moles of acetyl CoA are produced? ________ b)how many times would the fatty acid pass through the fatty acid spiral for complete oxidation? ________ c)what is the total ATP produced in the citric acid cycle? ________ d)how many moles of NADH are produced? ________ e)how many moles of FADH2 are produced? ________ f)how many moles of ATP are produced after all NADH are reoxidized in the respiratory chain? ________ g)how many moles of ATP are produced after all FADH2 are…arrow_forward
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