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Concept explainers
(a)
Interpretation:
Whether the “production of citrate from oxaloacetate and acetyl CoA” in citrate-malate shuttle system occur in the mitochondrial matrix or in the cytosol has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
Acetyl CoA is synthesized in mitochondria and then transported to cytosol through the citrate-malate shuttle system.
(b)
Interpretation:
Whether “ATP conversion to ADP” occurs in the mitochondrial matrix or in the cytosol in the citrate–malate shuttle system has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
Acetyl CoA is synthesized in mitochondria and then transported to cytosol through the citrate-malate shuttle system.
(c)
Interpretation:
Whether “the production of acetyl CoA and oxaloacetate from citrate” occur in the mitochondrial matrix or in the cytosol in the citrate–malate shuttle system has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
Acetyl CoA is synthesized in mitochondria and then transported to cytosol through the citrate-malate shuttle system.
(d)
Interpretation:
Whether “NADH is used as a reducing agent” in the mitochondrial matrix or in the cytosol in the citrate–malate shuttle system has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
Acetyl CoA is synthesized in mitochondria and then transported to cytosol through the citrate-malate shuttle system.
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Chapter 25 Solutions
EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
- Pyruvate is converted to Acetyl-CoA Select :- a. Through oxidative carboxylation process in the cytoplasm b.Through oxidative decarboxylation process in the mitochondrial matrix C. Through dehydration process in the mitochondrial matrix d.Through glucose-6-phosphatase in the liverarrow_forwardPyruvate is transformed to Acetyl-CoA in one of two ways: a. in the cytoplasm by an oxidative carboxylation process b.Through the mitochondrial matrix's oxidative decarboxylation mechanism C. In the mitochondrial matrix, via a dehydration process d.Through the liver's glucose-6-phosphatasearrow_forwardThe formation of acetyl CoA... A) occurs in the mitochondrial matrix, after moving across the outer and inner mitochondrial membrane. B) occurs in the cytoplasm prior to transport into the mitochondrial matrix. C) involves activation of acyl groups derived from pyruvate. D) A and C E) B and Carrow_forward
- Pyruvate is converted to Acetyl-CoA a. Through oxidative carboxylation process in the cytoplasm b. Through glucose-6-phosphatase in the liver c. Through dehydration process in the mitochondrial matrix d. Through aldolase in the cytoplasm e. Through oxidative decarboxylation process in the mitochondrial matrixarrow_forwardFatty acids are activated to acyl-CoAs and the acyl group is further transferred to carnitine because: a. Acyl-carnitines readily cross the mitochondrial inner membrane, but acyl-CoAs do not. b. Acyl-CoAs easily cross the mitochondrial membrane, but the fatty acids themselves will not. c. Carnitine is required to oxidize NAD+ to NADH. d. Fatty acids cannot be oxidized by FAD unless they are in the acyl-carnitine formarrow_forwardWhich of the following statements is NOT true about Krebs Cycle? a. Krebs cycle is composed of 8-step enzymatic reactions. b. For every CO2 released in the cycle, NADH is produced. c. Succinyl-CoA allows the phosphorylation of GDP (Guanosine Diphosphate) d. The carbon atoms from the glucose that enters the cycle are released from the mitochondrion immediately.arrow_forward
- Given that malonate inhibits succinate dehydrogenase which of the following statements is TRUE? a. FADH2 results in only 4 H+ being pumped out of the mitochondrial matrix. b. All electron transport is inhibited. c. Transfer of electrons from NADH to Coenzyme Q (ubiquinone) is inhibited. d. Transfer of electrons from FADH2 to Coenzyme Q (ubiquinone) is inhibited. e. NADH results in only 4 H+ being pumped out of the mitochondrial matrix. Clear my choicearrow_forwardOutline the role of carnitine in the transport of acyl-CoA molecules into the mitochondrion. How many enzymes are involved? What are they called?arrow_forwardWhich of the following statements about the TCA cycle is INCORRECT? a. All reactions of the TCA cycle take place in the cytosol. b. The energy released in the TCA cycle is mainly stored in the reduced electron carriers NADH and FADH2. c. The TCA cycle can recover much more energy than homolactic fermentation. d. Under aerobic conditions the TCA cycle is used to oxidize pyruvate. e. The TCA cycle is also called the citric acid cycle after the product of the first reaction catalyzed by pyruvate dehydrogenase.arrow_forward
- Which of the following statements concerning the glyoxylate cycle is false? a. In the glyoxylate cycle, acetyl-CoA reacts with glyoxylate to produce malate b. It bypasses part of the TCA cycle by converting isocitrate to glyoxylate and succinate. c. It usually occurs in the mitochondria d. It allows the organisms that possess this cycle to produce carbohydrates from fats. e. two molecules of acetyl-CoA can be converted to one molecule of oxaloacetatearrow_forwardAnimal cells metabolize fatty acids through a series of reactions that convert fatty acid chains to acetyl-CoA. These reactions also produce NADH and FADH2. Correctly complete the following statement: Animal cells can grow on fatty acids: O a. by respiration and by fermentation, but will grow faster by fermentation b. by fermentation but not by respiration c. by respiration and by fermentation, but will grow faster by respiration d. by respiration but not by fermentationarrow_forwardDuring cellular respiration, 60 molecules of CO2 were given off as waste. a. How many pyruvate molecules were produced in glycolysis? b. The total amount of ATP produced by complete cellular respiration would be? c. The amount of energy available (Net ATP) to cell as ATP would be?arrow_forward
- Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
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