Concept explainers
(a)
Interpretation: To indicate whether the statement “lactate is converted to pyruvate in the liver” relating to the Cori cycle is true or false.
Concept introduction: Glucose is converted to pyruvate by glycolysis
The Cori cycle is named after its discoverers, Gerty Radnitz Cori, and Carl Cori.
(b)
Interpretation: To indicate whether the statement “lactate travels from the liver to skeletal muscle via the bloodstream” relating to the Cori cycle is true or false.
Concept introduction: Glucose is converted to pyruvate by glycolysis metabolic pathway, pyruvate is further converted to lactate in the skeletal muscle cells by anaerobic reactions. The lactate is diffused into the bloodstream, by which it is transported to the liver. Lactate is reconverted to pyruvate. Gluconeogenesis metabolic pathway uses this pyruvate to synthesize glucose in the liver cells. Glucose is diffused into the bloodstream and is transported back to the active skeletal muscle cells. This cycle is known as the Cori cycle.
The Cori cycle is named after its discoverers, Gerty Radnitz Cori, and Carl Cori.
(c)
Interpretation: To indicate whether the statement “lactate is produced in the liver” relating to the Cori cycle is true or false.
Concept introduction: Glucose is converted to pyruvate by glycolysis metabolic pathway, pyruvate is further converted to lactate in the skeletal muscle cells by anaerobic reactions. The lactate is diffused into the bloodstream, by which it is transported to the liver. Lactate is reconverted to pyruvate. Gluconeogenesis metabolic pathway uses this pyruvate to synthesize glucose in the liver cells. Glucose is diffused into the bloodstream and is transported back to the active skeletal muscle cells. This cycle is known as the Cori cycle.
The Cori cycle is named after its discoverers, Gerty Radnitz Cori, and Carl Cori.
(d)
Interpretation: To indicate whether the statement “both lactate and pyruvate are present in the liver” relating to the Cori cycle is true or false.
Concept introduction: Glucose is converted to pyruvate by glycolysis metabolic pathway, pyruvate is further converted to lactate in the skeletal muscle cells by anaerobic reactions. The lactate is diffused into the bloodstream, by which it is transported to the liver. Lactate is reconverted to pyruvate. Gluconeogenesis metabolic pathway uses this pyruvate to synthesize glucose in the liver cells. Glucose is diffused into the bloodstream and is transported back to the active skeletal muscle cells. This cycle is known as the Cori cycle.
The Cori cycle is named after its discoverers, Gerty Radnitz Cori, and Carl Cori.
Want to see the full answer?
Check out a sample textbook solution
Chapter 24 Solutions
EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
- Which of the following statements are TRUE?Multiple answers are accepted for this question a .Two molecules of CO2 are produced each time a molecule of Acetyl-CoA is oxidized. b. During the first turn of the TCA Cycle the carbon atoms of Acetyl-CoA become CO2. c. The number of molecules of ATP that can be produced in the Citric Acid Cycle by substrate level phosphorylation of ADP from two molecules of Acetyl-CoA is 30. d. Fumarate contains a trans double bond. The cis isomer of Fumarate is Maleate which cannot serve as carbon source for a cell. e. Lack of O2 would decrease the rate of the Citric Acid Cycle in red blood cells. f. If a potent inhibitor of Succinyl-CoA Synthetaseis is applied to liver cells both energy production and synthesis of carbohydrate would be affected. g. The overall chemical changes that occur during one complete turn of the Citric Acid Cycle is the complete oxidation of one molecule of Acetyl-CoA plus the production of two molecules of CO2 plus the…arrow_forwardWhich of these statements about lactate dehydrogenase is true? a.It is a protein. b.It oxidizes lactic acid. c.It reduces another molecule (pyruvic acid). d.All of these are true.arrow_forwardWhich of the following reactions would be inhibited in the presence of large amounts of an egg white protein that binds and sequesters biotin? a. Pyruvate to Lactate b. Pyruvate to Alanine c. Phosphoenolpyruvate to Pyruvate d. Pyruvate to oxaloacetatearrow_forward
- Which of the following statements about the "central role" of TCA is/are correct? a. Some metabolic intermediates of TCA are used as non-carbohydrate sources for gluconeogenesis. b. β-oxidation of lipids produces acetyl-CoA that can enter TCA. c. All metabolic intermediates in TCA are used in the biosynthesis of amino acids. d. Degraded amino acids are converted to metabolic intermediates of TCA, then to ketone bodies.arrow_forwardStatin drugs are used to treat hypercholesterolemia because they a. prevent cholesterol from inserting in plasma membranes b. prevent cholesterol ester formation c. inhibit HMG-CoA reductase d. stimulate HMG-CoA synthasearrow_forwardWhich of the following enzymes possesses a catalytic mechanism extremely similar to that of the Pyruvate Dehydrogenase Complex? A. the isocitrate dehydrogenase B. the succinate dehydrogenase C. the alpha-ketoglutarate dehydrogenase D. the malate dehydrogenasearrow_forward
- A deficiency in sorbitol dehydrogenase cause all of the following except: Select one: O a. pathologic alternations related to Diabetes mellitus b. no lactose synthesis O c. lack of sperm motility O d. no fructose synthesisarrow_forwardWhich of the following enzyme catalyzes the conversion of pyruvate to lactate? Select one: a. Lactate reductase b. Pyruvate reductase C. Lactate dehydrogenase d. Pyruvate dehydrogenasearrow_forwardThe lactate produced by the LDH reaction during anaerobic glycolysis a. Is released to the blood stream and transported to the muscle where it is converted to glucose b. Is released to the blood stream and transported to the liver where it is converted to glucose. c. Is converted to fats via glyconeogensis in the muscle d. All of these answers are correct e. Is converted to glucose via glyconeogensis in the musclearrow_forward
- For each of the following conditions, state whether this condition would be occurring during gluconeogenesis, glycolysis, or both in liver cells. a. Transporting malate from the cytosol into the mitochondria. _____________ b. Transporting pyruvate from the cytosol into the mitochondria. _____________ c. We would have an increased (or increasing) concentration of F26BP. __________ d. Increased concentration of F6P.__________ e. Hexokinase IV (or glucokinase) is found in the nucleus of the cell. __________ f. The enzyme that synthesizes/breaks down F26BP is phosphorylated. __________ g. Elevated levels of glucagon in the blood. ____________arrow_forwardIf glucose was no longer available, pyruvate processing activity would: a. decrease b. increase c. remain the samearrow_forwardWhich of the following choices describes a likely metabolic consequence of thiamin deficiency in animals. Select one: a. Increased gas production in the rumen b. Impaired vision c. Decreased ATP synthesis d. Increased osmotic water influx into the lumen of the small intestine e. Increased serum cholesterol in the bloodarrow_forward
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education