Concept explainers
(a)
Interpretation: To determine the molecule that crosses the outer mitochondrial membrane in the cytosol to intermediate space direction in the
Concept introduction: In the glycolysis
Electron transfer chain is defined as a series of biochemical reactions in which the electrons and hydrogen ions
A transport system shuttle that involves
(b)
Interpretation: To identify the molecule that crosses the outer mitochondrial membrane in the intermembrane space to cytosol direction in the
Concept introduction: In the glycolysis metabolic pathway, a glucose molecule breaks down into two pyruvate molecules.ATP and NADH are produced along with pyruvate. The net overall equation for the glycolysis process is as follows:
Electron transfer chain is defined as a series of biochemical reactions in which the electrons and hydrogen ions
A transport system shuttle that involves
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EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
- You are studying the process of oxidative phosphorylation in the lab. You isolate several mitochondria from cells and place them in a buffered solution with a low pH and observe that the mitochondria begin to synthesize ATP. Which of the following is the best explanation for this observation? F It increases the conc. of OH-, causing the mitochondria to pump H+ to the intermembrane space. It increases the diffusion of H+ from the mitochondrial matrix to the intermembrane space. It increases the diffusion of H+ from the intermembrane space to the matrix. It increases the conc. of OH- in the mitochondrial matrix.arrow_forwardFigure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane "leaky" to protons. It was used until 1938 as a weight- loss drug. What effect would you expect DNP to have on the change in pH across the inner mitochondrial membrane? Why do you think this might be an effective weight-loss drug? Intermembrane space Mitochondrial matrix ATP Synthase ADP Inner mitochondrial membrane ATP Figure 7.11 ATP synthase is a complex, molecular machine that uses a proton (H) gradient to form ATP from ADP and inorganic phosphate (Pi). (Credit: modification of work by Klaus Hoffmeier)arrow_forwardThe glycerol-3-phosphate shuttle can transport cytosolic NADH equivalents into the mitochondrial matrix (see Fig. 15.11c). In this shuttle, the protons and electrons are donated to FAD, which is reduced to FADH₂. These protons and electrons are subsequently donated to coenzyme Q in the electron transport chain. End of Chapter Problem 86a How much ATP is generated per mole of glucose when the glycerol-3-phosphate shuttle is used? (Tolerance is +/- 2%) ATP are generated per glucose.arrow_forward
- Place the following molecules in the order in which they appear during aerobic respiration: Citrate G3P Glucose-6-phosphate Pyruvate Fructose-1,6-bisphosphate 1,3-bisphosphoglycerate 3-phosphoglycerate Glucose Acetyl-CoAarrow_forwardThe glycerol phosphate shuttle moves reducing equivalents (electrons) from the cytosol to the mitochondrial matrix. Which of the following is not a feature of this shuttle? a) Cytoplasmic glycerol phosphate dehydrogenase converts dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate. b) Mitochondrial glycerol phosphate dehydrogenase converts glycerol-3-phosphate to DHAP. c) Cytoplasmic NADH is oxidized to NAD+. d) Mitochondrial NAD+ is reduced to NADH. e) 1.5 ATPs are formed per cytoplasmic NADH shuttled.arrow_forward(b) The citric acid cycle is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate derived from carbohydrates into carbon dioxdide and chemical energy in the form of adenosine triphosphate (ATP). Clarify the association of citric acid cycle with electrons transport.arrow_forward
- Fill in the bold using the table. Because the inner mitochondrial membrane is impermeable to L, when there is an excess of mitochondrial L, it converts to M using a TCA condensation reaction, M crosses to the cytosol using a designated transport system. In the cytosol, M reconverts to L and oxaloacetate. Oxaloacetate is subsequently converted to malate with simultaneous production of N, a prerequisite cofactor for the glycolysis pathway. This reaction is then followed by conversion of N to pyruvate which produces O, a prerequisite cofactor for the fatty acid synthesis pathway. L M N O A. ATP pyruvate malate NADPH B. ATP citrate ATP NAD+ C. acetyl CoA pyruvate NAD+ NADH D. acetyl CoA citrate NAD+ NADPH E. glucose pyruvate malate NADP+arrow_forwardWhere is ATP produced by oxidative phosphorylation? (where is it located immediately after the moment of synthesis) Group of answer choices the mitochondrial matrix the cytoplasm the intermembrane space the inner mitochondrial membrane Which of the following most readily donates electrons? (strongest reducing agent) Group of answer choices NADH NAD+ Ubiquinone lactate Protons first enter ATP synthase through which subunit? Group of answer choices β c γ aarrow_forwardThe rate of oxygen consumption by mitochondria increases markedly when ADP is added and then returns to its initial value when the added ADP has been converted into ATP (Figure 18.39). Why does the rate decrease?arrow_forward
- An important function of the inner mitochondrial membrane is to provide a selectively permeable barrier to the movement of water soluble molecules and thus to generate different chemical environments on either side of the mem- brane. However, many of the substrates and products of oxidative phosphorylation are water soluble and must cross the inner membrane. How does this transport occur?arrow_forwardUsing the answer code on the right, indicate which form of energy production is being described: 1. takes place in the mitochondrial matrix 2. produces H2O as a by-product 3. results in a rich yield of ATP 4. takes place in the cytosol 5. processes acetyl-CoA 6. takes place in the mitochondrial innermembrane cristae 7. converts glucose into two pyruvate molecules 8. uses molecular oxygen 9. accomplished by the electron transport system and ATP synthase (a) glycolysis (b) citric acid cycle (c) oxidative phosphorylationarrow_forwardThe energy for the production of ATP comes from the breakdown of a glucose molecule via many enzyme-mediated chemical reactions occurring at several distinct stages of cellular respiration. During this time, the chemical energy stored in glucose is continually trans- ferred across these reactions. Which of the following describes the form in which most of the energy from the glucose molecule is stored just before the oxidative phosphorylation stage in aerobic cellular respiration? A B с D acetyl CoA FADH 2 NADH pyruvatearrow_forward
- Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning